Phospholipase Cγ in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity
Phospholipase Cγ in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity
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DOI：
10.1002/syn.20136
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发表时间：
2005-06-01
期刊：
影响因子：
2.3
通讯作者：
Nestler, EJ
中科院分区：
文献类型：
--
作者：
Bolaños, CA;Neve, RL;Nestler, EJ
神经营养因子及其激活的信号通路在介导与药物成瘾相关的长期分子、细胞和行为适应中发挥作用。本研究采用病毒介导的基因转移模拟慢性吗啡后腹侧被盖区（VTA）诱导磷脂酶c - γ (PLC γ)的生物学反应。使用行为致敏范式，我们证明将PLC-gamma 1微量注射到VTA的不同区域（吻侧和尾侧）会导致对吗啡的不同运动反应。[j], 2005。(c) 2005 Wiley-Liss, Inc。
Neurotrophic factors and the signaling pathways they activate play a role in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction. Here we mimicked the biological response of phospholipase C-gamma (PLC gamma) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral-mediated gene transfer. Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLC-gamma 1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine. Synapse 56:166-169, 2005. (c) 2005 Wiley-Liss, Inc.