Association Between Multiple Metal(loid)s Exposure and Blood Lipid Levels: Evidence from a Cross-Sectional Study of Southeastern China
Association Between Multiple Metal(loid)s Exposure and Blood Lipid Levels: Evidence from a Cross-Sectional Study of Southeastern China
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DOI：
10.1007/s12011-023-03951-2
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发表时间：
2023-11-22
影响因子：
3.9
通讯作者：
Fan，Guangqin
中科院分区：
文献类型：
--
作者：
Du，Guihua;Song，Xiaoguang;Fan，Guangqin
在现实生活中，接触必需金属和有毒金属的混合物同时发生。然而，关于共同暴露于多种金属（以下称为金属）对血脂水平的影响没有共识。因此，血液中的6种人体必需金属和5种有毒金属的浓度在720个一般人群从中国东南部同时测定作为一种措施的暴露。此外，分位数g-计算，贝叶斯核机器回归，弹性网络回归，和广义线性模型被用来调查的联合和个人的影响，暴露于这种金属混合物对人体血脂水平。暴露于这种金属混合物对血清总胆固醇（TC）水平的显著正联合效应，而不是对血清甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇、卡斯泰利风险指数I、卡斯泰利风险指数II、致动脉粥样硬化系数和非HDL-C水平的显著正联合效应。汞（Hg）暴露。此外，在TC水平的影响下，Pb和Hg之间存在协同效应，Se和Pb之间存在拮抗效应。我们的发现表明，这种金属混合物的组合暴露可能会影响人体血脂水平。因此，减少铅和汞等重金属的暴露应成为普通人群的优先事项。此外，还应谨慎考虑补硒。
Exposure to essential and toxic metals occurs simultaneously as a mixture in real-life. However, there is no consensus regarding the effects of co-exposure to multiple metal(loid)s (designated hereafter metals) on blood lipid levels. Thus, blood concentrations of six human essential metals and five toxic metals in 720 general populations from southeastern China were simultaneously determined as a measure of exposure. In addition, quantile g-computation, Bayesian kernel machine regression, elastic net regression, and generalized linear model were used to investigate both the joint and individual effects of exposure to this metal mixture on human blood lipid levels. The significant positive joint effect of exposure to this metal mixture on serum total cholesterol (TC) levels, rather than on serum triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, Castelli risk index I, Castelli risk index II, atherogenic coefficient, and non-HDL-C levels, was found. In addition, the positive effect may be primarily driven by selenium (Se), lead (Pb), and mercury (Hg) exposure. In addition, on the effect of TC levels, the synergistic effect between Pb and Hg and the antagonistic effect between Se and Pb were identified. Our finding suggests that combined exposure to this metal mixture may affect human blood lipid levels. Therefore, reducing exposure to heavy metals, such as Pb and Hg, should be a priority for the general population. In addition, Se supplementation should also be considered with caution.