Pharmacokinetics of digoxin in low-birth-weight infants.
Pharmacokinetics of digoxin in low-birth-weight infants.
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低出生体重婴儿中地高辛的药代动力学。
DOI：
10.1159/000481011
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
P. Ng
中科院分区：
文献类型：
--
作者：
R. Collins;D. Schiff;P. Ng
对13例需要地高辛治疗的低出生体重儿进行地高辛药代动力学研究。体重820 ~ 2710 g（平均1440 g），胎龄26 ~ 38周（平均30.9周）。地高辛的分布和消除可以用一个开放的双室模型来描述。分布容积（Vd - 95.7±1.0升/kg）与胎龄（GA）或体重（Wt）相关性较差。地高辛半衰期（47 +/- 21 h）与GA和Wt呈负相关（r分别为0.69和0.66），但总体地高辛清除率（29.8 +/- 14.7 ml/min/1.73 m2）高度依赖于这两个变量（r分别为0.87和0.88）。根据本研究结果和我们之前的调查，推荐地高辛的数字化和维持剂量。
Digoxin pharmacokinetics were studied in 13 low-birth-weight infants requiring digoxin therapy. Their weights ranged from 820 to 2,710 g (mean = 1,440 g) and gestational ages ranged from 26 to 38 weeks (mean = 30.9 weeks). The distribution and elimination of digoxin can be described by an open two-compartment model. Poor correlation between volume of distribution Vd beta 95.7 +/- 1.0 liters/kg) and gestational age (GA) or weight (Wt) was observed. Digoxin half-life (47 +/- 21 h) was inversely related to GA and Wt (r = 0.69 and 0.66, respectively), but total body digoxin clearance (29.8 +/- 14.7 ml/min/1.73 m2) was found to be highly dependent on these two variables (r = 0.87 and 0.88, respectively). According to the results of this study and our previous investigation, digitalizing and maintenance dosages of digoxin were recommended.