Organization of 'nanocrystal molecules' using DNA
Organization of 'nanocrystal molecules' using DNA
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DOI：
10.1038/382609a0
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发表时间：
1996-08-15
期刊：
影响因子：
64.8
通讯作者：
Schultz, PG
中科院分区：
文献类型：
--
作者：
Alivisatos, AP;Johnsson, KP;Schultz, PG
在纳米尺度上对物质进行图案化是当前材料化学和物理学的一个重要目标。这是由于需要进一步简化电子元件，以及在纳米尺度下，材料特性强烈依赖于尺寸，因此可以灵敏地调整（1）。在纳米晶体中，量子尺寸效应和大量的表面原子影响化学，电子，磁性和光学行为（2-4）。用于纳米级操作的“自上而下”（例如，光刻）方法仅达到纳米范围的上端（5）;但是“自下而上”湿化学技术允许制备尺寸仅为1-10 nm的单分散、无缺陷的微晶（6-10），控制纳米组装结构的方法很少。在这里，我们描述了一种策略，用于合成的“纳米分子”，其中离散数量的金纳米晶体被组织成基于沃森-克里克碱基配对相互作用的空间定义的结构。我们将确定长度和序列的单链DNA寡核苷酸连接到单个纳米晶体上，并在添加互补的单链DNA模板时组装成二聚体和三聚体。我们预计这种方法应该允许构建更复杂的二维和三维组件。
PATTERNING matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively(1). In nanoscale crystals, quantum size effects and the large number of surface atoms influence the, chemical, electronic, magnetic and optical behaviour(2-4). 'Top-down' (for example, lithographic) methods for nanoscale manipulation reach only to the upper end of the nanometre regime(5); but whereas 'bottom-up' wet chemical techniques allow for the preparation of monodisperse, defect-free crystallites just 1-10 nm in size(6-10), ways to control the structure of nanocrystal assemblies are scarce. Here we describe a strategy for the synthesis of 'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions. We attach single-stranded DNA oligonucleotides of defined length and sequence to individual nanocrystals, and these assemble into dimers and trimers on addition of a complementary single-stranded DNA template, We anticipate that this approach should allow the construction of more complex two- and three-dimensional assemblies.