NC/Nga mice: A mouse model for atopic dermatitis
NC/Nga mice: A mouse model for atopic dermatitis
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DOI：
10.1159/000053599
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发表时间：
1999-01-01
影响因子：
2.8
通讯作者：
Ra, C
中科院分区：
文献类型：
--
作者：
Suto, H;Matsuda, H;Ra, C
特应性皮炎是一种常见的瘙痒性疾病，主要发生在婴儿期和儿童期。AD的特点是发痒，患者有个体或家族的特应性疾病史。虽然AD也经常与血清IgE水平升高和常见的环境因素有关，但AD的病因尚不清楚。我们研究了NC/Nga小鼠（NC小鼠），这些小鼠显示AD样皮肤病变随年龄增长，可能是AD的小鼠模型。NC小鼠在常规（Conv）或特定无病原体（SPF）条件下维持。比较两组患者的临床症状、血清IgE水平及皮肤组织病理学变化，探讨其作为人类AD模型的应用价值。我们发现，在Conv条件下饲养的近交系NC小鼠的皮肤病变在临床和组织学上与人类AD非常相似，而在SPF条件下则不同，我们推测某些环境因素可能引发NC小鼠AD样体征和症状。为了进一步研究阿尔茨海默病的病理生理和治疗，绝对需要合适的动物模型，而NC小鼠在这方面非常有用。
Atopic dermatitis (AD) is a common pruritic disease that occurs primarily in infancy and childhood. AD is characterized by itching and the patient having an individual or family history of atopic diseases. Although AD is also frequently associated with elevated serum IgE levels and with common environmental factors contributing to its pathogenesis, the etiology of AD is still unknown. We examined NC/Nga mice (NC mice) that showed AD-like skin lesions with aging as a possible mouse model for AD. NC mice were maintained under conventional (Conv) or specific pathogen-free (SPF) conditions. Clinical symptoms, serum IgE levels and histopathology of the skin were compared between these 2 groups, and we explored their application as a model of human AD. It was found that the skin lesions of inbred NC mice were clinically and histologically very similar to human AD when the mice were raised under Conv conditions, but not under SPF conditions, and we assumed that some kinds of environmental factors might trigger AD-like signs and symptoms in NC mice. To further investigate the pathophysiology and treatment of AD, a suitable animal model is absolutely required, and NC mice are very useful for this purpose.