Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas
Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas
复制标题
丙型肝炎病毒相关边缘区淋巴瘤抗病毒治疗的反应
DOI：
10.1038/sj.leu.2403443
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发表时间：
2004
期刊：
影响因子：
11.4
通讯作者：
F. Dreyfus
中科院分区：
文献类型：
--
作者：
C. Kelaidi;F. Rollot;Sophie Park;M. Tulliez;B. Christoforov;Y. Calmus;P. Podevin;D. Bouscary;P. Sogni;P. Blanche;F. Dreyfus
流行病学研究表明，慢性丙型肝炎病毒（HCV）感染和低度B细胞淋巴瘤之间存在联系。边缘区淋巴瘤（MZL）包括脾淋巴瘤绒毛淋巴细胞是最常见的慢性HCV感染的设置中报告的亚组。在这项研究中，我们研究了8例HCV相关MZL患者的抗病毒治疗效果。我们发现八个病人中有五个对干扰素α和利巴韦林有反应。在某些情况下，血液学应答与病毒学应答相关。此外，我们报告了一个大颗粒淋巴细胞白血病发生与MZL和丙型肝炎病毒，并响应干扰素和利巴韦林。我们认为HCV和抗原驱动的淋巴组织增生性疾病之间存在病因学联系。
A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.
影响因子：
15.9
作者：
Epling-Burnette, PK;Liu, JH;Loughran, TP
通讯作者：
Loughran, TP