The role of thyroid hormone in testicular development and function.
The role of thyroid hormone in testicular development and function.
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DOI：
10.1677/joe-08-0218
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Maia AL
中科院分区：
文献类型：
--
作者：
Wagner MS;Wajner SM;Maia AL
甲状腺激素是几乎所有组织生长、发育和代谢的关键调节剂，甲状腺状态的改变会影响许多器官和系统。虽然睾丸多年来一直被认为是一个甲状腺激素无反应的器官，但现在证明甲状腺激素在睾丸发育和功能中起着重要作用。大量资料表明，甲状腺激素不仅影响精子发生，而且影响类固醇激素的生成。三碘甲状腺原氨酸（T3）参与控制支持细胞增殖和功能成熟，以及其在出生后Leydig细胞分化和类固醇生成中的作用被广泛接受。在整个发育过程中和成年期睾丸细胞中存在甲状腺激素受体，这意味着T3可能直接作用于这些细胞，从而产生影响。最近的几项研究采用了不同的方法和技术，试图了解甲状腺激素对睾丸细胞影响的机制。本文综述了甲状腺激素在男性性腺功能中的作用的最新研究进展。
Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis has been regarded as a thyroid hormone unresponsive organ, it is now evident that thyroid hormone plays an important role in testicular development and function. A considerable amount of data shows that thyroid hormone influences steroidogenesis as well as spermatogenesis. The involvement of triiodothyronine (T3) in the control of Sertoli cell proliferation and functional maturation is widely accepted, as well as its role in postnatal Leydig cell differentiation and steroidogenesis. The presence of thyroid hormone receptors in testicular cells throughout development and in adulthood implies that T3 may act directly on these cells to bring about its effects. Several recent studies have employed different methodologies and techniques in an attempt to understand the mechanisms underlying thyroid hormone effects on testicular cells. The current review aims at presenting an updated picture of the recent advances made regarding the role of thyroid hormones in male gonadal function.