Emerging Role of IGF-1 in Prostate Cancer: A Promising Biomarker and Therapeutic Target.
Emerging Role of IGF-1 in Prostate Cancer: A Promising Biomarker and Therapeutic Target.
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IGF-1在前列腺癌中的新作用：一个有前途的生物标志物和治疗靶点。
DOI：
10.3390/cancers15041287
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发表时间：
2023-02-17
期刊：
影响因子：
5.2
通讯作者：
Pan, Feng
中科院分区：
文献类型：
--
作者：
Liu, Guoqiang;Zhu, Minggang;Zhang, Mingrui;Pan, Feng
前列腺癌（PCa）影响全球数百万男性，约20%的PCa患者是在发展成致命的转移或去势抵抗状态后发现的。在前列腺癌中发现高水平的血清胰岛素样生长因子-1（IGF-1）和前列腺中活化的胰岛素样生长因子-1受体（IGF-1 R）。系统地了解IGF-1参与PCa进展的机制将加快新治疗方法的开发。本文综述了IGF-1在前列腺癌中的作用，并对今后前列腺癌的诊断和治疗进行了展望。前列腺癌（PCa）是一种由基因改变和微环境影响驱动的高度异质性疾病。越来越多的人认识到，不仅血清IGF-1水平升高，而且IGF-1 R及其下游信号组分的激活在PCa的发生发展中具有重要的驱动作用。因此，更好地了解IGF-1/IGF-1 R的活性和调节已成为PCa研究的重要课题。IGF-1/IGF-1 R信号传导影响癌细胞中的多种生物学过程，包括促进存活和更新，诱导迁移和扩散，以及促进对辐射和去势的抵抗力。因此，已经开发了靶向IGF-1/IGF-1 R的抑制剂以限制癌症发展。靶向IGF-1/IGF-1 R信号传导的多种药物已在肿瘤异种移植模型中显示出抗肿瘤生长的作用，但仍需要在临床试验中进一步验证其在PCa患者中的有效性。基于可靠的预测性生物标志物，将雄激素剥夺疗法或细胞毒性化疗药物与IGF-1 R拮抗剂相结合，并开发和应用新型药物，可能会提供更理想的结果。本文综述了IGF-1信号通路对前列腺癌发生发展的作用，并强调了该信号通路在癌症治疗中的重要性。
Prostate cancer (PCa) affects millions of men globally, and approximately 20% of PCa patients are found after they develop into a lethal metastatic or castration-resistant state. High levels of serum insulin-like growth factor-1 (IGF-1) and activated insulin-like growth factor-1 receptor (IGF-1R) in the prostate are found in PCa. A systematical understanding of the mechanisms of IGF-1 involved in PCa progression will expedite the development of new treatment approaches. The goal of this review is to summarize the literature on the role of IGF-1 in PCa to obtain a perspective regarding future scientific endeavors on PCa diagnosis and treatment. Prostate cancer (PCa) is a highly heterogeneous disease driven by gene alterations and microenvironmental influences. Not only enhanced serum IGF-1 but also the activation of IGF-1R and its downstream signaling components has been increasingly recognized to have a vital driving role in the development of PCa. A better understanding of IGF-1/IGF-1R activity and regulation has therefore emerged as an important subject of PCa research. IGF-1/IGF-1R signaling affects diverse biological processes in cancer cells, including promoting survival and renewal, inducing migration and spread, and promoting resistance to radiation and castration. Consequently, inhibitory reagents targeting IGF-1/IGF-1R have been developed to limit cancer development. Multiple agents targeting IGF-1/IGF-1R signaling have shown effects against tumor growth in tumor xenograft models, but further verification of their effectiveness in PCa patients in clinical trials is still needed. Combining androgen deprivation therapy or cytotoxic chemotherapeutics with IGF-1R antagonists based on reliable predictive biomarkers and developing and applying novel agents may provide more desirable outcomes. This review will summarize the contribution of IGF-1 signaling to the development of PCa and highlight the relevance of this signaling axis in potential strategies for cancer therapy.
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