Hippocampal shape analysis in Alzheimer's disease: A population-based study
Hippocampal shape analysis in Alzheimer's disease: A population-based study
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DOI：
10.1016/j.neuroimage.2006.12.036
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发表时间：
2007-05-15
期刊：
影响因子：
5.7
通讯作者：
Launer, L. J.
中科院分区：
文献类型：
--
作者：
Scher, A. I.;Xu, Y.;Launer, L. J.
背景海马萎缩-特别是CA 1区域的海马萎缩可以用作阿尔茨海默病（AD）或AD风险的生物标志物。AD海马体在体内与正常衰老或其他影响海马体的过程引起的变化的区别程度具有临床重要性，并且是一个活跃的研究领域。在这项研究中，我们使用结构成像技术来模拟海马的大小和区域形状之间的差异，老年男性与事件AD和一个非痴呆症的对照组的老年men.Methods：参与者是日裔美国男子从檀香山亚洲老龄化研究（哈斯）。自1965年以来一直对哈斯队列进行随访。以下分析基于1994-1996年接受MRI检查的男性亚组。参与者被诊断为AD事件（n = 24：年龄= 82.5 +/-：4.6）或非痴呆（n = 102：年龄= 83.0 +/- 5.9）。一位对痴呆诊断不知情的读者，使用已发表的标准手动勾勒出左右海马结构。我们使用神经成像实验室（LONI）开发的3D结构形状分析方法来比较AD病例和非痴呆对照组之间海马直径的区域变化。AD组海马总体积平均比非痴呆对照组小11.5（4903 +/- 857 mm（3）vs. 5540 +/- 805 mm（3）），左侧海马中位数（12.0%）和右侧海马中位数（11.6%）的大小差异相似。形状分析表明，AD和非痴呆海马之间的形状差异的区域模式，更明显的海马体比头部，和外观更一致的差异，在左侧海马比右侧。虽然使用该方法无法分配到特定的子区域，但表面变化主要与包含CA 1区域（以及邻近的CA 2和远端CA 3）、下托和齿状回门区的海马体区域相交。(C)2006年爱思唯尔公司All rights reserved.
Background. Hippocampal atrophy - particularly of the CA1 region may be useful as a biomarker for Alzheimer's disease (AD) or the risk for AD. The extent to which the AD hippocampus can be distinguished in vivo from changes due to normal aging or other processes that affect the hippocampus is of clinical importance and is an area of active research. In this study, we use structural imaging techniques to model hippocampal size and regional shape differences between elderly men with incident AD and a non-demented comparison group of elderly men.Methods: Participants are Japanese-American men from the Honolulu Asia Aging Study (HAAS). The HAAS cohort has been followed since 1965. The following analysis is based on a sub-group of men who underwent MRI examination in 1994-1996. Participants were diagnosed with incident AD (n = 24: age= 82.5 +/-:4.6) or were not demented (n = 102: age = 83.0 +/- 5.9). One reader, blinded to dementia diagnosis, manually outlined the left and right hippocampal formation using published criteria. We used 3D structural shape analysis methods developed at the Laboratory of Neuro Imaging (LONI) to compare regional variation in hippocampal diameter between the AD cases and the non-demented comparison group.Results: Mean total hippocampal volume was 11.5% smaller in the AD cases than the non-demented controls (4903 +/- 857 mm(3) vs. 5540 +/- 805 mm(3)), with a similar size difference for the median left (12.0%) and median right (11.6%) hippocampus. Shape analysis showed a regional pattern of shape difference between the AD and nondemented hippocampus, more evident for the hippocampal body than the head, and the appearance of more consistent differences in the left hippocampus than the right. While assignment to a specific sub-region is not possible with this method, the surface changes primarily intersect the area of the hippocampus body containing the CA1 region (and adjacent CA2 and distal CA3), subiculum, and the dentate gyrus-hilar region. (C) 2006 Elsevier Inc. All rights reserved.