Independent dose calculations for commissioning, quality assurance and dose reconstruction of PBS proton therapy
Independent dose calculations for commissioning, quality assurance and dose reconstruction of PBS proton therapy
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DOI：
10.1088/0031-9155/60/7/2819
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发表时间：
2015-04-07
影响因子：
3.5
通讯作者：
Lomax, A. J.
中科院分区：
文献类型：
--
作者：
Meier, G.;Besson, R.;Lomax, A. J.
铅笔束扫描质子疗法允许通过提供数千个铅笔束来提供高度共形的剂量分布。在这项工作中，我们描述了Paul Scherrer研究所开发的用于独立剂量计算的工具包，该工具包允许在治疗工作流程中的多个点进行剂量重建。通过铅笔束比较，基于重建的剂量分布的质量保证被证明是有利于铅笔束的，以检测输送不确定性并估计其影响。独立剂量计算工具的设计允许剂量计算参数(例如，深度剂量分布、角度空间分布)的高度可修改性，从而允许在临床治疗计划系统之外的安全环境中调查这些参数对结果剂量分布的影响，从而区分对测量剂量偏差的不同贡献。提出的系统可能会潜在地减少目前构成临床工作流程瓶颈的患者特定质量保证测量的数量。
Pencil beam scanning proton therapy allows the delivery of highly conformal dose distributions by delivering several thousand pencil beams. These beams have to be individually optimised and accurately delivered requiring a significant quality assurance workload.In this work we describe a toolkit for independent dose calculations developed at Paul Scherrer Institut which allows for dose reconstructions at several points in the treatment workflow. Quality assurance based on reconstructed dose distributions was shown to be favourable to pencil beam by pencil beam comparisons for the detection of delivery uncertainties and estimation of their effects. Furthermore the dose reconstructions were shown to have a sensitivity of the order of or higher than the measurements currently employed in the clinical verification procedures.The design of the independent dose calculation tool allows for a high modifiability of the dose calculation parameters (e.g. depth dose profiles, angular spatial distributions) allowing for a safe environment outside of the clinical treatment planning system for investigating the effect of such parameters on the resulting dose distributions and thus distinguishing between different contributions to measured dose deviations. The presented system could potentially reduce the amount of patient-specific quality assurance measurements which currently constitute a bottleneck in the clinical workflow.