A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.
A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.
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SET8 的功能性单核苷酸多态性可预测乳腺癌
DOI：
10.18632/oncotarget.9099
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Liu B;Zhang X;Song F;Liu Q;Dai H;Zheng H;Cui P;Zhang L;Zhang W;Chen K
SET8基因3′非翻译区（3′-UTR）内的一个单核苷酸多态性（SNP）位点rs16917496（T > C）与包括乳腺癌在内的多种恶性肿瘤的易感性相关。为进一步阐明该SNP在乳腺癌预后中的相关性，我们对1190例乳腺癌患者进行了一项临床研究以及SET8表达分析。我们发现，TT基因型患者的SET8表达水平高于CC基因型患者，且SET8高表达与患者生存率低相关。乳腺癌肿瘤组织中的SET8表达水平显著高于配对的癌旁正常组织。此外，对315例患者的生存分析显示，SNP rs16917496是乳腺癌预后的一个独立预测因子，与CC/CT基因型相比，TT基因型患者生存率较低。因此，该SNP可能作为乳腺癌的一个遗传预后因子及治疗靶点。未来有必要开展进一步研究。
A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3′-untranslated region (3′-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer. To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival. SET8 expression was significantly higher in breast tumor tissue than in paired adjacent normal tissue. In addition, survival analysis in 315 patients showed SNP rs16917496 was an independent prognostic factor of breast cancer outcome with TT genotype associated with poor survival compared with CC/CT genotypes. Thus, this SNP may serve as a genetic prognostic factor and a treatment target for breast cancer. Future studies are warranted.
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影响因子：
16
作者：
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