Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking
Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking
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DOI：
10.1016/s0091-3057(97)00474-7
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发表时间：
1998-03-01
影响因子：
3.6
通讯作者：
Froehlich, JC
中科院分区：
文献类型：
--
作者：
Krishnan-Sarin, S;Wand, GS;Froehlich, JC
Beta-funaltrexamine (beta-FNA), a selective mu opioid receptor antagonist, when administered in doses of 10.0, 15.0, and 20.0 mg/kg b.wt., decreased alcohol but not water intake in a dose-dependent manner in rats selectively bred for high alcohol intake (HAD line). Beta-FNA also suppressed the intake of a saccharin solution containing alcohol without altering the intake of a similar solution without alcohol. The results suggest that beta-FNA may prove useful as a pharmacotherapeutic agent for the treatment of alcohol dependence. In a second study, pituitary beta-endorphin gene expression (proopiomelanocortin or POMC messinger ribonucleic acid-mRNA) was compared in another pair of rat lines selectively bred for high or low alcohol intake (alcohol preferring or P and alcohol-nonpreferring or NP lines). A repeated alcohol challenge (1.0 g/kg b.wt./day, IP for 4 days) produced a greater increase in POMC mRNA in the anterior and neurointermediate lobes of the pituitary of P rats compared with NP rats. The results suggest that a genetic predisposition toward high alcohol drinking may be associated with increased responsiveness of the opioid system to alcohol. (C) 1998 Elsevier Science Inc.
