Nanostructure-assisted optical tweezers for microspectroscopic polymer analysis
Nanostructure-assisted optical tweezers for microspectroscopic polymer analysis
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DOI：
10.1038/s41428-020-00410-w
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发表时间：
2020-09
期刊：
影响因子：
2.8
通讯作者：
T. Shoji;Yasuyuki Tsuboi
中科院分区：
文献类型：
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作者：
T. Shoji;Yasuyuki Tsuboi
溶解在溶液中的单个聚合物链和纳米珠的拉曼/荧光显微光谱分析将成为研究其分子结构和特性的有力分析方法。基于这个动机，我们专注于光学捕获软物质的拉曼显微光谱的使用。利用近红外激光束的局部光热效应和光动力作用，形成了聚N-异丙基丙烯酰胺等温敏聚合物链的微组装体。通过使用这种方法，我们开发了一种确定聚合物微组装中聚合物浓度的技术。此外，我们展示了一种基于等离子体纳米结构上的微组装的分子凝聚和检测技术。对于这种分子凝聚和检测过程，局部表面等离子体激元在等离子体激元纳米结构周围的光学力增强和局部温度升高中起着至关重要的作用。最后，针对更小的软纳米材料的新型操纵方法，介绍了纳米结构光镊辅助（NASSCA）。本文综述了高分子链和纳米微球的光学操控方法及其在分析化学中的应用。
Raman/fluorescence microspectroscopic analysis of individual polymer chains and nanobeads dissolved in solution will become a powerful analytical method to study their molecular structure and characteristics. With this motivation, we focused on the use of Raman microspectroscopy for optically trapped soft matter. A tightly focused near-infrared laser beam formed a microassembly of thermoresponsive polymer chains such as poly(N-isopropylacrylamide) due to a local photothermal effect and optical force. By using this method, we developed a technique for determining the polymer concentration in a polymer microassembly. Furthermore, we demonstrated a molecular condensation and detection technique based on microassembly on plasmonic nanostructures. For this molecular condensation and detection process, localized surface plasmons play an essential role in the optical force enhancement and local temperature increase around the plasmonic nanostructures. Finally, aiming toward novel manipulation methods of smaller soft nanomaterials, nanostructured semiconductor-assisted (NASSCA) optical tweezers are introduced. In this paper, we reviewed the optical manipulation methods of polymer chains and nanobeads and their applications in analytical chemistry.