Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children
Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children
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DOI：
10.5664/jcsm.8778
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发表时间：
2020-12-15
影响因子：
4.3
通讯作者：
Takaoka, Yutaka
中科院分区：
文献类型：
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作者：
Kimura, Shigemi;Toyoura, Makiko;Takaoka, Yutaka
研究目的：探讨治疗后昼夜节律睡眠-觉醒障碍症状的改善是否与血清胰岛素样生长因子-1(IGF-1)浓度升高有关。方法：87例学龄儿童(男32例，女55例)，年龄14.31+/-1.50岁(平均+/-标准差)。(2)早上6：00或07：00开始光疗；(3)每天进行轻度运动(如步行20~30分钟)。结果：两组患者治疗前后平均入睡时间分别为23：32+/-4.21和10：27+/-2.98，平均入睡时间为21：26+/-0.55和06：50+/-0.70。与治疗前相比，治疗后各时间点的平均入睡时间和睡眠偏移时间均显著提前(P
Study Objectives: We aimed to investigate whether improvements in the symptoms of circadian rhythm sleep-wake disorder after treatment were associated with an increase in serum insulin-like growth factor-1 (IGF-1) concentration.Methods: Eighty-seven school-aged children (32 males, 55 females), aged 14.31 +/- 1.50 years (mean +/- standard deviation), who were admitted to our hospital with circadian rhythm sleep-wake disorder received treatment for 6-8 weeks consisting of the following protocol: (1) lights-out for sleep occurred at 21:00, (2) phototherapy for waking started at 06:00 or 07:00, and (3) light exercise was required every day (eg, a 20-to 30-minute walk). Blood samples were collected at 08:00 AM to measure the serum concentrations of IGF-1, pre-and posttreatment.Results: The mean times of day of sleep onset and offset at the pre-and posttreatment timepoints were 23:32 +/- 4.21 and 10:27 +/- 2.98, and 21:26 +/- 0.55 and 06:50 +/- 0.70, respectively. The mean times of day of sleep onset and offset measured at the posttreatment timepoint were significantly earlier compared with the pretreatment baselines (P