Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats
Preventive Effects of Zinc Against Psychological Stress-Induced Iron Dyshomeostasis, Erythropoiesis Inhibition, and Oxidative Stress Status in Rats
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DOI：
10.1007/s12011-011-9319-z
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发表时间：
2012-06-01
影响因子：
3.9
通讯作者：
Shen, Hui
中科院分区：
文献类型：
--
作者：
Li, Yingjie;Zheng, Yuanyuan;Shen, Hui
心理应激可引起机体铁的吸收和再分配减少，导致骨髓铁浓度降低，抑制红细胞生成。在本研究中，我们研究了补充锌对ps诱导大鼠铁代谢、红细胞生成和氧化应激状态的影响。将32只大鼠随机分为对照组和补锌组。每组又分为对照组和PS组。大鼠在通讯箱建立的PS暴露前给予补锌。我们调查了血清皮质酮（CORT）水平；铁的表观吸收率；肝、脾、皮质、海马、纹状体、血清中铁含量；血液参数;丙二醛(MDA);还原性谷胱甘肽（GSH）；和超氧化物歧化酶（SOD）与正常饮食的ps处理大鼠相比，补充锌的ps处理大鼠的铁表观吸收量增加，血清铁、血红蛋白、红细胞、谷胱甘肽和SOD活性增加；血清CORT；肝、脾、脑局部铁含量；MDA降低。上述结果表明，饲粮中添加锌对ps诱导的大鼠铁代谢失调、红细胞生成抑制和氧化应激状态具有预防作用。
Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.