Mechanistic study of the influence of micelle solubilization and hydrodynamic factors on the dissolution rate of solid drugs.
Mechanistic study of the influence of micelle solubilization and hydrodynamic factors on the dissolution rate of solid drugs.
复制标题
胶束增溶和流体动力学因素对固体药物溶出速率影响的机理研究。
DOI：
10.1002/jps.2600570608
复制
发表时间：
1968
影响因子：
3.8
通讯作者：
W. Higuchi
中科院分区：
文献类型：
--
作者：
P. Singh;S. J. Desai;D. Flanagan;A. Simonelli;W. Higuchi
研究了胶束-药物增溶对溶出速率的影响。对扩散层模型、Danckwerts理论和旋转盘理论预测的溶解速率进行了计算，并与苯佐卡因-聚山楂酸酯80体系的实验数据进行了比较。所有涉及的参数都是独立确定的。讨论了每一种理论适用的不同条件。设计了不同种类的溶解实验，以产生每种理论适用的条件。这些研究中涉及的理论和实验程序为区分机制提供了一种独特的方法，并且在未来的研究中应该是有用的，例如，在研究搅拌对间期运输机制的影响时。
The influence of micelle-drug solubilization on the dissolution rate has been investigated. The dissolution rates predicted by the diffusion layer model, the Danckwerts theory, and by the rotating disk theory were calculated and compared with experimental data obtained for the benzocaine-polysorbate 80 system. All the parameters involved were independently determined. The different conditions under which each of these theories is applicable have been discussed. Different kinds of dissolution experiments were designed to produce the conditions under which each theory would apply. The theoretical and experimental procedures involved in these studies provide a unique method for distinguishing mechanisms and should be useful in future studies, e.g. , in studies of the effects of agitation on mechanisms of interphase transport.