Survival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer
Survival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer
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DOI：
10.1002/ijc.10667
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发表时间：
2002-11-10
影响因子：
6.4
通讯作者：
Vasen, HFA
中科院分区：
文献类型：
--
作者：
Boks, DES;Trujillo, AP;Vasen, HFA
子宫内膜癌（EC）是与遗传性非息肉病性结直肠癌（HNPCC）相关的最常见的结外肿瘤。与一般人群相比，HNPCC增加了患EC的风险。HNPCC患者的预后优于普通散发性结直肠癌患者。然而，目前尚不清楚hnpcc相关EC的生存率是否高于散发性EC。本研究的目的是比较hnpcc相关EC与散发性EC的生存率。来自荷兰遗传肿瘤基金会的登记，来自46个家族的50名hnpcc相关EC患者携带生殖系突变或符合阿姆斯特丹标准11，与荷兰埃因霍温癌症登记处登记的100名散发性EC患者年龄和分期匹配。分析生存率。hnpcc相关EC患者的总体5年累积生存率为88%，散发性EC患者为82% （p = 0.59）。在IA期、IB期和IC期，hnpcc相关EC和散发EC患者的生存率分别为92%和91% （p = 0.90）。在IIIA期和IIIC期，hnpcc相关EC和散发性EC的生存率分别为72%和50% （p = 0.38）。此外，研究组与对照组的肿瘤组织学亚型分布无显著差异（p = 0.55）。在一般人群和来自HNPCC家族的女性中，EC患者的生存结局没有显著差异。这些结果可能对我们理解EC和早期筛查的作用有重要意义。(C) 2002 Wiley-Liss, Inc。
Endometrial carcinoma (EC) is the most common extra-colonic tumor associated with hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC increases the risk of EC compared to the general population. Patients with HNPCC have a better prognosis than patients with common sporadic colorectal cancer. It is unknown, however, whether the survival rate of HNPCC-associated EC is higher than that of sporadic EC. The aim of our study was to compare the survival rates of HNPCC-associated EC with sporadic EC. From the registry of the Netherlands Foundation for Hereditary Tumors, 50 patients with HNPCC-associated EC from 46 families harboring a germline mutation or fulfilling the Amsterdam Criteria 11 were age- and stage-matched with 100 patients with sporadic EC registered in the Eindhoven Cancer Registry in the Netherlands. Survival rates were analyzed. The overall 5-year cumulative survival rates for patients with HNPCC-associated EC was 88% and 82% for patients with sporadic EC (p = 0.59). In Stages IA, IB and IC, the survival rates of patients with HNPCC-associated EC and sporadic EC were 92% and 91%, respectively (p = 0.90). In Stages IIIA and IIIC, the survival rates for HNPCC-associated EC and sporadic EC were 72% and 50%, respectively (p = 0.38). Furthermore, there was no significant difference in the distribution of tumor histologic subtypes in the study and control groups (p = 0.55). The outcomes in survival in EC in the general population and in women from families with HNPCC do not differ significantly. These results may have important implications in our understanding of EC and the role of early screening. (C) 2002 Wiley-Liss, Inc.