Effect of smoking cessation on mortality after myocardial infarction -: Meta-analysis of cohort studies
Effect of smoking cessation on mortality after myocardial infarction -: Meta-analysis of cohort studies
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DOI：
10.1001/archinte.160.7.939
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发表时间：
2000-04-10
影响因子：
--
通讯作者：
Cook, D
中科院分区：
文献类型：
--
作者：
Wilson, K;Gibson, N;Cook, D
目的：确定戒烟对心肌梗死后死亡率的影响。数据来源：使用 MEDLINE 和 EMBASE 关键字搜索检索 1966 年至 1996 年发表的英语和非英语文章，并辅以致作者信和检索评论参考书目。研究选择：相关摘要和文章的选择由 2 位独立审稿人进行。选择的文章报告了队列研究的结果，该研究检查了心肌梗死后戒烟与继续吸烟的患者的死亡率。数据提取：死亡率数据由 2 位独立审稿人从所选文章中提取。数据综合：纳入了 12 项研究，其中包含 5878 名患者的数据。这些研究于 1949 年至 1988 年间在 6 个国家进行。随访时间从 2 年到 10 年不等。所有研究均表明戒烟可降低死亡率。基于随机效应模型，戒烟者心肌梗死后死亡的综合优势比为 0.54（95% 置信区间，0.46-0.62）。各项研究的相对风险降低幅度为 15% 至 61%。假设继续吸烟者的死亡率为 20%，则需要戒烟才能挽救 1 条生命，人数为 13 人。无论性别、随访时间、研究地点和时间段如何，死亡率获益都是一致的。结论：多项队列研究的结果表明，心肌梗塞后戒烟与死亡率显着降低相关。
Objective: To determine the effect of smoking cessation on mortality after myocardial infarction.Data Sources: English- and non-English-language articles published from 1966 through 1996 retrieved using keyword searches of MEDLINE and EMBASE supplemented by letters to authors and searching bibliographies of reviews.Study Selection: Selection of relevant abstracts and articles was performed by 2 independent reviewers. Articles were chosen that reported the results of cohort studies examining mortality in patients who quit vs continued smoking after myocardial infarction.Data Extraction: Mortality data were extracted from the selected articles by 2 independent reviewers.Data Synthesis: Twelve studies were included containing data on 5878 patients. The studies took place in 6 countries between 1949 and 1988. Duration of follow-up ranged from 2 to 10 years. All studies showed a mortality benefit associated with smoking cessation. The combined odds ratio based on a random effects model for death after myocardial infarction in those who quit smoking was 0.54 (95% confidence interval, 0.46-0.62). Relative risk reductions across studies ranged from 15% to 61%. The number needed to quit smoking to save 1 life is 13 assuming a mortality rate of 20% in continuing smokers. The mortality benefit was consistent regardless of sex, duration of followup, study site, and time period.Conclusion: Results of several cohort studies suggest that smoking cessation after myocardial infarction is associated with a significant decrease in mortality.