The role of infections and coinfections with newly identified and emerging respiratory viruses in children.
The role of infections and coinfections with newly identified and emerging respiratory viruses in children.
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DOI：
10.1186/1743-422x-9-247
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发表时间：
2012-10-27
期刊：
影响因子：
4.8
通讯作者：
Clementi M
中科院分区：
文献类型：
--
作者：
Debiaggi M;Canducci F;Ceresola ER;Clementi M
急性呼吸道感染是发达国家和发展中国家儿童发病的主要原因。过去几十年来，在儿童急性下呼吸道感染（LRTI）中反复检测到多种呼吸道病毒，包括呼吸道合胞病毒（RSV）、甲型和乙型流感病毒、副流感病毒（PIV）、腺病毒、鼻病毒（HRV）。然而，在过去十年中，由于分子技术的进步，新发现的病毒已被识别，包括人类偏肺病毒（hMPV）、冠状病毒NL63（HcoV-NL63）和HKU1（HcoV-HKU1）、人类博卡病毒（HBoV）、新型肠道病毒（HEV）、副肠病毒（HpeV）和鼻病毒 (HRV) 株、多瘤病毒 WU (WUPyV) 和 KI (KIPyV) 以及大流行的 H1N1v 甲型流感病毒。这些发现极大地改变了先前关于呼吸道感染的知识，主要强调儿童群体会接触各种具有相似季节性模式的病毒。在这种情况下，建立新发现的病毒与疾病之间的因果关系以及混合感染与疾病严重程度增加之间的关联可能具有挑战性。本综述将概述新认识的以及主要新出现的呼吸道病毒，并重点关注它们对儿童 LRTI 感染和合并感染的影响。
Acute respiratory infections are a major cause of morbidity in children both in developed and developing countries. A wide range of respiratory viruses, including respiratory syncytial virus (RSV), influenza A and B viruses, parainfluenza viruses (PIVs), adenovirus, rhinovirus (HRV), have repeatedly been detected in acute lower respiratory tract infections (LRTI) in children in the past decades. However, in the last ten years thanks to progress in molecular technologies, newly discovered viruses have been identified including human Metapneumovirus (hMPV), coronaviruses NL63 (HcoV-NL63) and HKU1 (HcoV-HKU1), human Bocavirus (HBoV), new enterovirus (HEV), parechovirus (HpeV) and rhinovirus (HRV) strains, polyomaviruses WU (WUPyV) and KI (KIPyV) and the pandemic H1N1v influenza A virus. These discoveries have heavily modified previous knowledge on respiratory infections mainly highlighting that pediatric population is exposed to a variety of viruses with similar seasonal patterns. In this context establishing a causal link between a newly identified virus and the disease as well as an association between mixed infections and an increase in disease severity can be challenging. This review will present an overview of newly recognized as well as the main emerging respiratory viruses and seek to focus on the their contribution to infection and co-infection in LRTIs in childhood.