Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value
Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value
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DOI：
10.1073/pnas.93.3.1093
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发表时间：
1996-02-06
影响因子：
11.1
通讯作者：
Sommer, SS
中科院分区：
文献类型：
--
作者：
Kovach, JS;Hartmann, A;Sommer, SS
具有突变的p53抑癌基因的人类癌细胞具有选择性生长优势，并且可能对电离辐射和某些化疗药物具有抵抗力。为了检查p53基因突变的预后价值，对90名中西部高加索乳腺癌患者进行了方法学分析，几乎可以检测到所有突变的100%，p53基因突变的存在是迄今为止最能预测复发和死亡的单一指标(相对风险分别为4.7和23.2)，直接检测p53突变比免疫组织化学检测p53过表达具有更大的预后价值，分析p53基因突变可以识别乳腺癌患者的一部分，尽管缺乏预后不良的常规指标，但早期复发和死亡的风险很高。
Human cancer cells with a mutated p53 tumor-suppressor gene have a selective growth advantage and may exhibit resistance to ionizing radiation and certain chemotherapeutic agents, To examine the prognostic value of mutations in the p53 gene, a cohort of 90 Midwestern Caucasian breast cancer patients were analyzed with methodology that detects virtually 100% of all mutations, The presence of a p53 gene mutation was by far the single most predictive indicator for recurrence and death (relative risks of 4.7 and 23.2, respectively), Direct detection of p53 mutations had substantially greater prognostic value than immunohistochemical detection of p53 overexpression, Analysis of p53 gene mutations may permit identification of a subset of breast cancer patients who, despite lack of conventional indicators of poor prognosis, are at high risk of early recurrence and death.