USE OF POLYMERASE CHAIN-REACTION TO DEMONSTRATE CYTOMEGALOVIRUS DNA IN CSF OF PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
USE OF POLYMERASE CHAIN-REACTION TO DEMONSTRATE CYTOMEGALOVIRUS DNA IN CSF OF PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
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DOI：
10.1212/wnl.43.1_part_1.75
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发表时间：
1993-01-01
期刊：
影响因子：
9.9
通讯作者：
STORCH, GA
中科院分区：
文献类型：
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作者：
CLIFFORD, DB;BULLER, RS;STORCH, GA
我们使用聚合酶链反应（PCR），以显示巨细胞病毒（CMV）DNA在脑脊液中的CMV神经根脊髓病综合征的患者。为了研究这一发现的意义，我们还进行了PCR CMV的CSF样本从30例人类免疫缺陷病毒（HIV）感染和神经系统疾病，4例实体器官移植患者，其中3例活动性CMV感染，和10例患者没有临床怀疑的HIV或CMV感染。CMV DNA仅在HIV患者中存在，并且更常见于有脊髓功能障碍证据的患者中。我们的研究结果表明，PCR可能是有用的，在快速诊断CMV感染的中枢神经系统的HIV患者和脊髓根病综合征可能只代表一个频谱的CMV引起的脊髓功能障碍的一部分，在这些患者。
We used the polymerase chain reaction (PCR) to demonstrate cytomegalovirus (CMV) DNA in the CSF of a patient with the CMV radiculomyelopathy syndrome. To investigate the significance of this finding, we also performed PCR for CMV on CSF samples from 30 patients with human immunodeficiency virus (HIV) infection and neurologic disease, four patients with solid organ transplants including three with active CMV infection, and 10 patients with no clinical suspicion of HIV or CMV infection. There was CMV DNA only in patients with HIV, and it was present more often in patients with evidence of spinal cord dysfunction. Our results suggest that PCR may be useful in the rapid diagnosis of CMV infection of the CNS in patients with HIV and that the radiculomyelopathy syndrome may represent only part of a spectrum of CMV-induced spinal cord dysfunction in these patients.