COMPLEXATION OF METAL-IONS BY MONENSIN - CRYSTAL AND MOLECULAR-STRUCTURE OF HYDRATED AND ANHYDROUS CRYSTAL FORMS OF SODIUM MONENSIN
COMPLEXATION OF METAL-IONS BY MONENSIN - CRYSTAL AND MOLECULAR-STRUCTURE OF HYDRATED AND ANHYDROUS CRYSTAL FORMS OF SODIUM MONENSIN
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DOI：
10.1021/ja00542a010
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发表时间：
1980-01-01
影响因子：
15
通讯作者：
STRONG, PD
中科院分区：
文献类型：
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作者：
DUAX, WL;SMITH, GD;STRONG, PD
在无水和二水晶体形式中观察到的钠-莫能菌素配合物的构象与先前报道的Ag+配合物和NaBr配合物几乎相同。二水合物在正交空间群P212121中结晶（a = 16.387(4)）。， b = 18.684(4)。， c = 12.792(3)。， Z = 4)，无水配合物在单斜空间群P21中结晶（a = 9.218(5)）。， b = 12.702 (1) . ang。， c = 16.274(7)。度量。= 101.02 (1).degree., Z = 2)。所有金属配合物的构象都不同于游离酸的羧酸构象、热-尾氢键构象和5元环中的1个构象。如果莫能菌素对复杂金属离子的能力部分归因于5元C环的柔韧性，则可能通过甲基取代该环来修饰莫能菌素，从而稳定特定的构象。[这一信息对离子跨膜传输的研究很重要]。
The conformations of the sodium-monensin complex observed in anhydrous and dihydrate crystal forms are nearly identical with one another, with the previously reported Ag+ complex and with a complex with NaBr. The dihydrate crystallizes in the orthorhombic space group P212121 (a = 16.387 (4) .ANG., b = 18.684 (4) .ANG., c = 12.792 (3) .ANG., Z = 4) and the anhydrous complex crystallizes in the monoclinic space group P21 (a = 9.218 (5) .ANG., b = 12.702 (1) .ANG., c = 16.274 (7) .ANG., .beta. = 101.02 (1).degree., Z = 2). The conformations of all of the metal complexes differ from that of the free acid in the carboxylic acid conformation, the heat-to-tail H-bonding and the conformation of 1 of the 5 membered rings. If the ability of monensin to complex metal ions is partly attributable to the flexibility of the 5-membered C ring, it may be possible to modify monensin by methyl substitutions on this ring, stabilizing a particular conformation. [This information is important to the study of ion transport across membrane.].