A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China
A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China
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DOI：
10.1016/j.meegid.2015.07.012
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发表时间：
2015-08-01
影响因子：
3.2
通讯作者：
Zheng, Yong-Tang
中科院分区：
文献类型：
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作者：
Gong, Xiaohong;Liu, Yanyan;Zheng, Yong-Tang
尽管反复暴露于HIV-1，一些人仍然没有感染，这表明遗传因素赋予宿主对HIV-1获得的抵抗力。趋化因子受体CCR 5、CXCR 4及其主要配体SDF 1在HIV-1进入靶细胞过程中起重要作用。为探讨HIV-1基因变异与HIV-1感染的关系，对921名男性静脉吸毒者（HIV-1暴露阳性者263人，HIV-1暴露阴性者658人）的CCR 5、CXCR 4和SDF 1基因11个常见SNPs进行了基因分型。根据是否共享共享信息，将整个队列分为共享信息（SS）和不共享信息（SNS）两个亚组。结果发现，在SNS亚组中，SDF 1基因rs 17540465在HESP和HESN两组间的等位基因频率和基因型频率差异有统计学意义，而在SS亚组中差异无统计学意义。与SNS的HESN相比，SNS的HESP携带显著更少的等位基因A，表明等位基因A对HIV-1感染的保护作用。共用注射器的注射吸毒者由于直接将感染HIV-1的血液传递给他人，因此被认为是HIV-1感染的高危人群。对于不与他人共享毒品的注射吸毒者来说，性接触可能是HIV-1传播的主要途径。考虑到两个亚群之间HIV-1的不同转染途径，我们推测SDF 1可能有助于通过性交途径感染HIV-1。(C)2015爱思唯尔B. V.保留所有权利。
Despite repeated exposures to HIV-1, some individuals remain uninfected, suggesting that genetic factors confer host resistance to HIV-1 acquisition. The chemokine receptors CCR5, CXCR4 and the principal ligand SDF1 of CXCR4 play an important role for the entry of HIV-1 to target cells. To explore the relationship between genetic variants and HIV-1 infection, 11 common SNPs in CCR5, CXCR4 and SDF1 were genotyped in 921 male intravenous drug users (IDUs), of which 263 individuals were HIV-1-exposed seropositive (HESP) and 658 were HIV-1-exposed seronegative (HESN). According to the situation of syringe-sharing, the whole cohort was divided into two subgroups: syringe-sharing (SS) and syringe-not-sharing (SNS). We found that in the SNS subgroup rs17540465 of SDF1 showed significant difference of allele and genotype frequencies between HESP IDUs and HESN IDUs, but not in the SS subgroup. HESP with SNS carried significantly less allele A compared with HESN with SNS, indicating a protective role of allele A against HIV-1 infection. Syringe-sharing IDUs are supposed to be exposed highly to HIV-1 infection risk due to the direct transfer of HIV-1 infected blood to another. For syringe-not-sharing IDUs, sexual contact may be the major route of HIV-1 transmission. Considering the different route of HIV-1 transfection between two subgroups, we speculate that SDF1 may contribute susceptibility to HIV-1 infection in the route of sexual intercourse. (C) 2015 Elsevier B.V. All rights reserved.