Antinociceptive activity of Ricinus communis L. leaves
Antinociceptive activity of Ricinus communis L. leaves
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DOI：
10.1016/s2221-1691(11)60012-9
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发表时间：
2011-04-01
影响因子：
1.7
通讯作者：
Patil, Ravindra Y.
中科院分区：
文献类型：
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作者：
Taur, Dnyaneshwar J.;Waghmare, Maruti G.;Patil, Ravindra Y.
目的：蓖麻（大戟科）是一种药用植物，其叶子可用于治疗烧伤、炎症和类风湿性关节炎。本研究旨在评估蓖麻叶甲醇提取物 (MRCL) 的抗伤害活性。方法：采用乙酸诱导的扭体试验、福尔马林诱导的舔爪法和尾浸法评价小鼠剂量为100,125和150 mg/kg体重时的镇痛活性。结果：结果表明 MRCL 对小鼠的三种经典疼痛模型表现出相当大的抗伤害活性。初步植物化学分析表明存在皂苷、类固醇和生物碱。结论：Mitt：I.具有抗伤害潜力，这可能是由于其中含有皂苷、类固醇和生物碱。
Objective: Ricinus communis Linn (Euphorbiaceae) is a medicinal plant, and its leaves are useful in treating burns, inflammation and rheumatoid arthritis. The present study was undertaken to evaluate antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). Methods: Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100,125 and 150 mg/kg body weight. Results: The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids. Conclusions: Mitt: I. possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.