Longitudinal syndromal and sub-syndromal symptoms after severe depression: 10-year follow-up study
Longitudinal syndromal and sub-syndromal symptoms after severe depression: 10-year follow-up study
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DOI：
10.1192/bjp.184.4.330
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发表时间：
2004-04-01
影响因子：
10.5
通讯作者：
Paykel, ES
中科院分区：
文献类型：
--
作者：
Kennedy, N;Abbott, R;Paykel, ES
背景
很少有抑郁症的后续研究在阈值和亚阈值水平上对抑郁症状随时间的变化进行评估。
目的
评估一次严重抑郁症发作后的长期纵向症状病程。
方法
来自先前研究队列的共61名参与者接受了一次详细访谈，涵盖了8 - 11年随访期间抑郁症的纵向病程和药物治疗情况。
结果
在随访的月份中，52%处于无症状水平，15%处于轻微症状水平，20%处于残留症状水平，13%处于完全抑郁水平。此外，30%的随访月份处于抑郁症发作期，18%的患者在随访期间从未达到无症状状态。在最初2年后，每个症状水平的患者百分比保持相对稳定，但个体的水平有波动，平均每个随访年症状水平有两次变化。
结论
在严重发作之后，抑郁症的亚综合征水平很常见且持续存在，有相当大的波动，这表明亚综合征亚型和完全抑郁症之间存在连续性。
利益声明
无。资金详情见致谢部分。
Background Few follow-up studies of depression have evaluated depressive symptomatology over time at both threshold and sub-threshold levels.Aims To evaluate long-term longitudinal symptomatic course after an episode of severe depression.Method A total of 61 participants from a previous study cohort underwent a detailed interview covering the longitudinal course of depression and pharmacological treatment over 8-11 years of follow-up.Results Of the follow-up months, 52% were spent at an asymptomatic level, 15% at minor symptom level, 20% at residual symptom level and 13% at full depression level. Also, 30% of follow-up months were spent in an episode of depression, and 18% of patients never achieved asymptomatic status during follow-up. The percentage of patients at each symptom level remained relatively stable after the first 2 years, but levels in individuals fluctuated, with a mean of two changes in symptom levels per follow-up year.Conclusions After severe episodes, sub-syndromal levels of depression are common and persistent, with considerable fluctuation suggesting a continuum between sub-syndromal subtypes and full depression.Declaration of interest None. Funding detailed in Acknowledgements.