The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.
The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.
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DOI：
10.1016/j.jmb.2013.08.023
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发表时间：
2013-12-13
影响因子：
5.6
通讯作者：
DeFilippis, Victor R.
中科院分区：
文献类型：
--
作者：
Amsler, Lisi;Verweij, Marieke C.;DeFilippis, Victor R.
人类巨细胞病毒（HCMV）是β-疱疹病毒家族的一员，尽管针对感染有一致的多管齐下的抗病毒免疫反应，但它总是会终生占据宿主。这种持久性是由大型病毒基因组实现的，该基因组编码因子赋予各种复杂的，通常是冗余的表型，这些表型禁用或以其他方式操纵有影响的免疫效应过程。I型干扰素系统是宿主抵御病毒感染的第一道防线。分泌干扰素诱导的生理反应可有效阻断包括HCMV在内的多种病毒类型的复制。因此，病毒必须表现出对抗这些反应的机制，包括它们的抑制、耐受或重新利用。本综述的目的是描述I型干扰素系统对HCMV复制的影响，并展示病毒所采用的策略的数量和多样性，这些策略允许在存在干扰素依赖活性的情况下感染宿主。
Human cytomegalovirus (HCMV) is a member of the β-herpesvirus family that invariably occupies hosts for life despite a consistent multi-pronged antiviral immune response that targets the infection. This persistence is enabled by the large viral genome that encodes factors conferring a wide assortment of sophisticated, often redundant phenotypes that disable or otherwise manipulate impactful immune effector processes. The type I interferon system represents a first line of host defense against infecting viruses. The physiological reactions induced by secreted interferon act to effectively block replication of a broad spectrum of virus types, including HCMV. As such, the virus must exhibit counteractive mechanisms to these responses that involve their inhibition, tolerance, or re-purposing. The goal of this review is to describe the impact of the type I interferon system on HCMV replication and to showcase the number and diversity of strategies employed by the virus that allow infection of hosts in the presence of interferon-dependent activity.
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