A hydrodynamic switch: Microfluidic separation system for magnetic beads
A hydrodynamic switch: Microfluidic separation system for magnetic beads
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DOI：
10.1063/1.3123809
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发表时间：
2009-04
影响因子：
4
通讯作者：
A. Weddemann;F. Wittbracht;A. Auge;A. Hütten
中科院分区：
文献类型：
--
作者：
A. Weddemann;F. Wittbracht;A. Auge;A. Hütten
在这项工作中，介绍了一种用于分离连续流动中的小磁性颗粒的装置，该装置由两个由连接通道连接的微流体通道组成。应用两种不同的流速，可以结合流体动力学和磁泳效应分离颗粒。两种不同的流速引入了额外的自由度，其使得微流体几何形状能够充当流体动力学开关，其可以克服扩散贡献，使得装置适用于100 nm以下尺寸的颗粒。基于有限元方法的理论预测进行了比较实验观察。
In this work a device for separating small magnetic particles in continuous flow is introduced, consisting of two microfluidic channels that are connected by a junction channel. Applying two different flow rates, particles can be separated combining hydrodynamic and magnetophoretic effects. The two different flow rates introduce an additional degree of freedom that enables the microfluidic geometry to act as a hydrodynamic switch that can overcome diffusive contributions making the device applicable for particles of the size scale below 100 nm. Theoretical predictions based on finite element methods are compared to experimental observations.