Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism
Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism
复制标题
富含二十碳五烯酸的磷脂通过介导胆固醇代谢改善动脉粥样硬化
DOI：
10.1016/j.jff.2017.02.020
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发表时间：
2017-05-01
影响因子：
5.6
通讯作者：
Wang, Yuming
中科院分区：
文献类型：
--
作者：
Ding, Lin;Zhang, Lingyu;Wang, Yuming
膳食鱼油可通过改善脂代谢来防治动脉粥样硬化；在载脂蛋白E缺陷(apoE(-/-))小鼠中，鱼油对降低血脂水平无效，但仍具有抗动脉粥样硬化的作用。到目前为止，还没有直接证据比较评估富含二十二碳六烯酸和二十碳五烯酸的磷脂(DHA-PL和EPA-PL)对apoE(-/-)小鼠动脉粥样硬化的影响。本研究表明，1%DHA-PL和EPA-PL均能显著减轻高脂饮食apoE(-/-)小鼠的动脉粥样硬化病变(分别为37.4%和53.4%)。EPA-PL通过调节肝脏胆固醇代谢相关基因的mRNA和蛋白水平显著降低血清和肝脂水平，而DHA-PL则无效。在抑制主动脉促炎细胞因子方面，DHA-PL在降低TNF-α、IL-6和IL-1β转录方面优于EPA-PL。综上所述，DHA-PL的抗炎作用仅限于抗炎作用，而EPA-PL的作用主要是改善脂代谢，改善动脉粥样硬化。(C)2017爱思唯尔有限公司。保留所有权利。
Dietary fish oil could prevent and treat atherosclerosis by improving lipid metabolism; in apolipoprotein E-deficient (apoE(-/-)) mice, it was ineffective at lowering serum lipid levels but still showed anti atherosclerosis action. To date, no direct evidence has comparatively evaluated the effect of docosahexaenoic acid-enriched and eicosapentaenoic acid-enriched phospholipids (DHA-PL and EPA-PL) on atherosclerosis in apoE(-/-) mice. The present study suggested that both 1% dietary DHA-PL and EPA-PL could significantly reduce atherosclerotic lesions (37.4% and 53.4%, respectively) in high fat diet apoE(-/-) mice. EPA-PL significantly decreased serum and hepatic lipid levels, by mediating mRNA and protein levels of genes related to hepatic cholesterol metabolism, whereas DHA-PL was ineffective. In the suppression of aortic proinflammatory cytokines, DHA-PL was superior to EPA-PL at reducing TNF-alpha, IL-6, and IL-1 beta transcription. In conclusion, the action of DHA-PL was simply anti-inflammatory, and that of EPA-PL was mainly the improvement of lipid metabolism in the amelioration of atherosclerosis. (C) 2017 Elsevier Ltd. All rights reserved.