Thyroid function tests in patients undergoing bone marrow transplantation.
Thyroid function tests in patients undergoing bone marrow transplantation.
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接受骨髓移植的患者的甲状腺功能检查。
DOI：
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发表时间：
1990
影响因子：
4.8
通讯作者：
R. Champlin
中科院分区：
文献类型：
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作者：
J. Hershman;E. Eriksen;N. Kaufman;R. Champlin
对27例接受骨髓移植的患者进行了前瞻性的甲状腺功能研究，以确定该方法及其后遗症对血清甲状腺激素水平和促甲状腺激素分泌的影响。几乎所有患者的血清三碘甲状腺原氨酸和游离三碘甲状腺原氨酸浓度均降至低于正常水平；15例患者的游离甲状腺激素浓度低于正常水平。在血清T3浓度降至最低点时，用灵敏的免疫放射测定法测定的9例患者的血清促甲状腺激素浓度显著下降并降至低于正常水平。这些数据表明，移植后血清甲状腺激素水平的降低至少部分归因于促甲状腺激素分泌的抑制。
Thyroid function was studied prospectively in 27 patients receiving bone marrow transplants to determine the effect of this procedure and its sequelae on serum thyroid hormone levels and thyrotropin secretion. Serum triiodothyronine and free triiodothyronine concentrations declined to subnormal levels in nearly all of the patients; free thyroxine concentration became subnormal in 15 patients. At the time of the nadir of the serum T3 concentration, serum thyrotropin concentration, measured by a sensitive immunoradiometric assay, declined significantly and became subnormal in nine patients. The data suggest that the reduction of serum thyroxine levels after transplantation is attributable, at least in part, to inhibition of thyrotropin secretion.