Adverse childhood experiences and self-reported liver disease - New insights into the causal pathway
Adverse childhood experiences and self-reported liver disease - New insights into the causal pathway
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DOI：
10.1001/archinte.163.16.1949
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发表时间：
2003-09-08
影响因子：
--
通讯作者：
Anda, RF
中科院分区：
文献类型：
--
作者：
Dong, M;Dube, SR;Anda, RF
目的：为了研究不良童年经历（ACES），包括虐待，忽视和家庭功能障碍的形式，肝脏疾病的风险评估的作用的风险行为，如药物滥用和高风险的性活动，作为介质的ACES肝脏疾病relationships.Methods：回顾性队列研究数据收集了17337成人健康计划成员通过调查。Logistic回归校正了年龄、性别、种族和教育程度，用于评估ACE与肝病关系的强度以及介质在这种关系中的影响。
Objective: To examine the relationship of adverse childhood experiences (ACES), including abuse, neglect, and forms of household dysfunction, to the risk of liver disease by assessing the role of risk behaviors, such as substance abuse and high-risk sexual activity, as mediators of the ACEs-liver disease relationship.Methods: Retrospective cohort study data were collected from 17337 adult health plan members through a survey. Logistic regression adjusted for age, sex, race, and education was used to estimate the strength of the ACEs-liver disease relationship and the impact of the mediators in this relationship.Results: Each of 10 ACEs increased the risk of liver disease 1.2 to 1.6 times (P