Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer: A case-control study
Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer: A case-control study
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DOI：
10.3892/etm.2010.152
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发表时间：
2010-11-01
影响因子：
2.7
通讯作者：
Akazawa, Kohei
中科院分区：
文献类型：
--
作者：
Chen, Jun;Zhang, Nan;Akazawa, Kohei
饮酒和吸烟对食道癌患病率的影响因国家、种族和生活方式的不同而有很大差异。关于饮酒和吸烟的数量和持续时间之间的相互作用对食道癌发病率影响的数据很少。在这项病例对照研究中，病例包括年龄小于60岁、经组织学证实为食管鳞状细胞癌（ESCC）的患者，招募时间为2002年1月1日至2006年12月31日。对照组在体检时未发现异常。通过将每个病例与性别和年龄匹配的对照配对，总共创建了 835 对。使用条件逻辑回归分析来估计调整后的比值比 (OR) 和 95% 置信区间。单变量条件逻辑回归分析显示，根据饮酒时间和吸烟时间的 OR 单调增加。饮酒和吸烟可能对食管鳞癌的发生有协同作用。使用向前逐步选择程序的条件逻辑回归分析表明，ESCC 的发病率与吸烟时间、饮酒量和饮酒时间之间的相互作用以及癌症家族史有关。特别是，饮酒时间长、酒精摄入量高的群体的 OR 远高于饮酒时间短、摄入量低的群体，这凸显了饮酒量和饮酒时间之间相互作用的重要性。这项研究证实了饮酒和吸烟之间的相互作用在食管癌中的重要性。数量和持续时间之间的这种相互作用是估计饮酒和吸烟导致食道癌风险的准确指标。这些发现表明，减少中青年饮酒者和吸烟者的数量将降低食道癌的发病率。
The effects of alcohol consumption and tobacco smoking on the prevalence of esophageal cancer vary considerably by country, race and lifestyle. Few data exist on the effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the incidence of esophageal cancer. In this case-control study, the cases included patients with histologically confirmed esophageal squamous cell carcinoma (ESCC) younger than 60 years of age and recruited between January 1, 2002 and December 31, 2006. The controls had no abnormality during a medical checkup. A total of 835 pairs were created by pairing each case to a gender- and age-matched control. Conditional logistic regression analysis was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals. Univariate conditional logistic regression analyses revealed that the ORs according to both duration of alcohol consumption and tobacco smoking increased monotonically. Alcohol consumption and tobacco smoking may have a synergistic effect on the incidence of ESCC. Conditional logistic regression analysis using a forward stepwise selection procedure revealed that the incidence of ESCC was associated with the duration of tobacco smoking, the interaction between the amount and duration of alcohol consumption, and a family history of cancer. In particular, groups with a long duration of alcohol consumption and high alcohol intake had much higher ORs than those with short duration and low intake, which highlights the importance of the interaction between the amount and duration of alcohol intake. This study confirmed the significance of the interaction between alcohol consumption and tobacco smoking in esophageal cancer. This interaction between amount and duration is an accurate indicator for estimating the risk of esophageal cancer attributable to alcohol consumption and tobacco smoking. These findings suggest that decreasing the number of young and middle-aged drinkers and smokers will reduce the incidence of esophageal cancer.