Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.
Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events.
复制标题
在海马锋利的波浪纹波事件中，协调的激发和抑制前额叶的集合。
DOI：
10.1016/j.neuron.2016.02.010
复制
发表时间：
2016-04-06
期刊：
影响因子：
16.2
通讯作者：
Frank LM
中科院分区：
文献类型：
--
作者：
Jadhav SP;Rothschild G;Roumis DK;Frank LM
海马体和前额皮质 (PFC) 之间的相互作用对于学习和记忆至关重要。清醒尖波波纹 (SWR) 事件期间的海马活动对于空间学习很重要，海马 SWR 活动通常代表过去或潜在的未来经历。这种重新激活是否或如何参与 PFC，以及重新激活如何与正在进行的 PFC 活动模式相互作用仍不清楚。我们记录了学习空间任务的动物的海马 CA1 和 PFC 活动，发现许多 PFC 细胞在 SWR 期间表现出尖峰调制。与 CA1 不同，PFC 中的 SWR 相关活动包括不同群体的兴奋和抑制。在单个 SWR 中，兴奋激活具有与同时重新激活的海马表征相关的表征的 PFC 细胞，而抑制则抑制具有不相关表征的 PFC 细胞。因此，清醒的 SWR 标志着海马体和前额皮层之间的强烈协调时间，这反映了与持续体验相关的表征的结构化重新激活。
Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation engages the PFC, and how reactivation might interact with ongoing patterns of PFC activity remains unclear. We recorded hippocampal CA1 and PFC activity in animals learning spatial tasks and found that many PFC cells showed spiking modulation during SWRs. Unlike in CA1, SWR-related activity in PFC comprised both excitation and inhibition of distinct populations. Within individual SWRs, excitation activated PFC cells with representations related to the concurrently reactivated hippocampal representation, while inhibition suppressed PFC cells with unrelated representations. Thus, awake SWRs mark times of strong coordination between hippocampus and PFC that reflects structured reactivation of representations related to ongoing experience.