Further studies on the influence of the intraocular pressure on aqueous humor dynamics in cynomolgus monkeys
Further studies on the influence of the intraocular pressure on aqueous humor dynamics in cynomolgus monkeys
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眼压对食蟹猴房水动态影响的进一步研究
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发表时间：
1967
期刊：
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通讯作者：
A. Bill
中科院分区：
文献类型：
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作者：
A. Bill
一只眼用13 ′ 1-白蛋白测定前房的整体流出率，另一只眼用1 ZS I-白蛋白。在16只自发性眼压为8.0 ± 0.7 mm Hg的眼睛中，葡萄膜巩膜流量为0.63 ± 0.08 nL/min，快速血管途径流量为0.53 ± 0.07 fIL/min。当眼内压降低到2或4毫米汞柱，让水流入水库，前房液引流到血液中的快速路线的方式几乎完全停止。在2毫米汞柱下，进入葡萄膜巩膜途径的总流量平均减少63%，但在4毫米汞柱下，5只眼睛中有4只葡萄膜巩膜流量正常。通过从储液器流入调节眼内压从自发水平至35 mm Hg，使进入全身循环的平均流出量比对照眼高12.0 ± 2.3 pL/min。葡萄膜巩膜血流无明显增加。伪设施为0.055 ± 0.013 fiL/min/mm Hg。死眼葡萄膜巩膜血流在较宽的压力范围内表现出压力敏感性。可以得出结论，在食蟹猴中，房水通过传统的血管途径进入巩膜外静脉，并通过葡萄膜巩膜途径排出其高分子成分进入脉络膜上和巩膜外组织。然而，葡萄膜血管中的胞饮作用对于房水的大量引流几乎没有作用。在活的食蟹猴眼中，在8至35 mm Hg的范围内，根据IOP = PB +（Fn-Fu）/（Cg - 0.06），眼内压（IOP）由受体静脉压（Pv）、房水形成的净速率（Fn）、通过葡萄膜巩膜途径的房水流出速率（Fu）和流出的总便利度Co确定。
13 '1-albumin was used to determine the rate of bulk outflow from the anterior chamber in one eye and 1ZS I-albumin was used in the other. In 16 eyes at a spontaneous intraocular pressure of 8.0 ± 0.7 mm. Hg, uveoscleral flow was 0.63 ± 0.08 nL per minute and flow by fast, vascular routes was 0.53 ± 0.07 fiL per minute. When the intraocular pressure was lowered to 2 or 4 mm. Hg by letting aqueous flow into a reservoir, drainage of anterior chamber fluid into the blood by way of fast routes stopped almost completely. At 2 mm. Hg the bulk flow into the uveoscleral routes was reduced by an average of 63 per cent, but at 4 mm. Hg uveoscleral flow was normal in 4 of 5 eyes. Adjusting the intraocular pressure from the spontaneous level to 35 mm. Hg by inflow from a reservoir gave an average outflow into the general circulation that was 12.0 ± 2.3 pL per minute higher than in the control eyes. Uveoscleral flow was not raised significantly. Pseudofacility was 0.055 ± 0.013 fiL per minute per millimeter Hg. In dead eyes uveoscleral flow appeared to be pressure sensitive in a wider pressure range than in living eyes. It is concluded that in cynomolgus monkeys aqueous humor passes out through the conventional vascular routes into the episcleral veins and passes out through uveoscleral routes that drain its high molecular components into the suprachoroid and the episcleral tissues. However, pinocytosis, in the uveal blood vessels} plays little role for bulk drainage of aqueous humor. In living cynomolgus eyes, within the range 8 to 35 mm. Hg, the intraocular pressure (IOP) is determined by the recipient venous pressure (Pv), the net rate of aqueous humor formation (Fn), the rate of aqueous outflow by uveoscleral routes (Fu), and the gross facility of outflow Co according to IOP = PB + (Fn - Fu)/(Cg - 0.06).