APPLICATIONS OF NUCLEAR MAGNETIC CROSS-RELAXATION SPECTROSCOPY TO TISSUES
APPLICATIONS OF NUCLEAR MAGNETIC CROSS-RELAXATION SPECTROSCOPY TO TISSUES
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DOI：
10.1002/mrm.1910170216
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发表时间：
1991-02-01
影响因子：
3.3
通讯作者：
BRYANT, RG
中科院分区：
文献类型：
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作者：
GRAD, J;MENDELSON, D;BRYANT, RG
水非均相体系中的磁交叉弛豫是一个长期存在的现象，它使得系统混合物的可观察到的衰减常数具有更基本的弛豫时间，这些弛豫时间表征了耦合组分的弛豫。通过利用组织中水自旋和固定自旋之间的磁弛豫耦合，水质子信号强度可用于间接映射与组织中固定组分的1h NMR谱直接相关的频率响应。该方法应用于许多大鼠组织，以确定组织之间是否存在显著差异，这些差异可能在本实验应用于诊断磁成像中被利用。在研究的9个大鼠组织中发现了显著的差异，这表明实验方法可以用于在磁性图像上叠加基本的新信息，即组织中通常不可观察的固定化大分子成分的动态特征。©1991学术出版社，Inc。
Magnetic cross‐relaxation in aqueous heterogeneous systems is a long established phenomenon that makes the observable decay constants for the system mixtures of more fundamental relaxation times which characterize the relaxation of the coupled components. By exploiting the magnetic relaxation coupling between the water spins and the immobilized spins in a tissue, the water‐proton‐signal intensity may be used to map indirectly a frequency response that is directly related to the1H NMR spectrum of the immobilized components of the tissue. This method is applied to a number of rat tissues to determine whether there are significant differences among tissues that might be exploited in applications of this experiment to diagnostic magnetic imaging. Significant differences are found among nine rat tissues studied, which suggests that the experimental approach may be used to superimpose fundamentally new information, the dynamic character of the usually unobservable immobilized macromolecular components of the tissue, on a magnetic image. © 1991 Academic Press, Inc.