A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants
A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants
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DOI：
10.1038/s41392-022-00879-2
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发表时间：
2022
影响因子：
39.3
通讯作者：
Yan Jinghua
中科院分区：
文献类型：
--
作者：
Duan Xiaomin;Shi Rui;Liu Pulan;Huang Qingrui;Wang Fengze;Chen Xinyu;Feng Hui;Huang Weijin;Xiao Junyu;Yan Jinghua
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants threatens efforts to contain the coronavirus disease 2019 (COVID-19) pandemic.Omicron (B.1.1.529),the fifth novel SARS-CoV-2 variant of concern (VOC),harbors 15 mutations in the receptor-binding domain (RBD) of the spike (S) protein.These mutations include almost all the sites of existing VOCs (Alpha/B.1.1.7,Beta/B.1.351,Gamma/P.1,and Delta/B.1.617.2).Importantly,the key mutations directly interact with the ACE2 receptor and constitute the main target of neutralizing antibodies (NAbs),which is believed to alter the sensitivity to a large number of NAbs.
