DNA methylation in zebrafish.
DNA methylation in zebrafish.
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DOI：
10.1016/b978-0-12-387685-0.00005-6
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发表时间：
2011
影响因子：
--
通讯作者：
Halpern ME
中科院分区：
文献类型：
--
作者：
Goll MG;Halpern ME
DNA甲基化对于许多大基因组真核生物的正常发育和细胞分化至关重要。小型热带淡水鱼Danio rerio（斑马鱼）最近成为研究DNA甲基化的强大系统，特别是在发育的背景下。这篇综述总结了我们目前对斑马鱼DNA甲基化的了解，并为哺乳动物该系统的普遍保护提供了证据。此外，新兴的战略强调，使用鱼模型来解决一些关键的DNA甲基化研究中悬而未决的问题。
DNA methylation is crucial for normal development and cellular differentiation in many large-genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently emerged as a powerful system for the study of DNA methylation, especially in the context of development. This review summarizes our current knowledge of DNA methylation in zebrafish and provides evidence for the general conservation of this system with mammals. In addition, emerging strategies are highlighted that use the fish model to address some of the key unanswered questions in DNA methylation research.