Single-dose effects of marihuana smoke. Bronchial dynamics and respiratory-center sensitivity in normal subjects.
Single-dose effects of marihuana smoke. Bronchial dynamics and respiratory-center sensitivity in normal subjects.
复制标题
大麻烟雾的单剂量影响。
DOI：
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发表时间：
1973
影响因子：
158.5
通讯作者：
E. Gaensler
中科院分区：
文献类型：
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作者：
L. Vachon;M. Fitzgerald;N. Solliday;I. A. Gould;E. Gaensler
摘要有大麻吸烟史的正常志愿者使用袋盒技术吸入每公斤大麻3.23毫克的总烟雾。随机地，9人接受了含有高浓度(2.6%)的大麻，8人接受了低浓度(1.0%)的Delta9四氢大麻酚。分别于吸烟前和吸烟后20min监测生理指标。在高剂量组，心率增加了28%。与此同时，在人体体积描记仪中测量的气道阻力下降了38%；功能残余容量始终保持不变(±50毫升)，而比气道传导性增加了44%。流量-容量环显示流量在肺活量的25%时增加了45%。低剂量组的心率没有增加，但在呼吸道动力学方面出现了显著的变化，尽管变化较小。通过重复呼吸测量的二氧化碳敏感性在两组中都保持不变。大麻烟雾与香烟烟雾不同，会导致支气管扩张。
Abstract Normal volunteers with previous marihuana smoking experience inhaled the total smoke from 3.23 mg per kilogram of marihuana, using a bag-in-box technic. Randomly, nine received marihuana containing a high (2.6 per cent), and eight a low (1.0 per cent) concentration of delta-9 tetrahydrocannabinol. Physiologic variables were monitored before and for 20 minutes after smoking. In the high-dose group the heart rate increased 28 per cent. Concomitantly, airway resistance, measured in a body plethysmograph, fell 38 per cent; the functional residual capacity remained unchanged (± 50 ml) throughout, and specific airway conductance increased 44 per cent. Flow-volume loops showed a 45 per cent increase in flow rate at 25 per cent of vital capacity. The low-dose group showed no increase in heart rate but significant, if lesser changes, in airways dynamics. Carbon dioxide sensitivity, measured by rebreathing remained unchanged in both groups. Marihuana smoke, unlike cigarette smoke, causes bronchodilatation ...