Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct.
Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct.
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DOI：
10.1136/bmjopen-2023-072098
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发表时间：
2023-09-22
期刊：
影响因子：
2.9
通讯作者：
Johnston, Jill
中科院分区：
文献类型：
--
作者：
Hempel, Susanne;Danz, Margie;Robinson, Karen A;Bolshakova, Maria;Rodriguez, Jesus;Mears, Alanna;Pham, Cindy;Yagyu, Sachi;Motala, Aneesa;Tolentino, Danica;Akbari, Omid;Johnston, Jill
多重化学敏感性（MCS）的特点是，据报告，对被认为对一般人群无毒的低剂量普通化学剂（例如香水、油漆、清洁产品和其他吸入或摄入的化学剂）的环境暴露产生不良反应。目前对于MCS是否可以被确定为一种独特的疾病还没有达成共识。文献的范围审查将以五个问题为指导：MCS是如何定义的？提出了哪些诊断标准？用什么方法报告MCS的患病率和发病率？关于MCS是否是一种明显的疾病或综合征的科学证据有哪些特点？科学文献中提出了MCS的潜在机制是什么？在实证研究中对MCS的哪些治疗和管理方法进行了评估？我们将在14个研究数据库中进行全面检索。引文筛选将由机器学习算法支持。两名独立审稿人将根据预先规定的标准评估全文出版物的资格。数据抽象将支持简明的证据表。正式的谘询活动将收集有关检讨结果和简报的意见。现有的研究证据将以证据地图的形式以用户友好的可视化方式记录下来。确定免于审查（UP-22-00516）。结果将通过期刊手稿传播，数据将通过在线数据存储库公开获取。该协议在开放科学框架（osf.io/4a3wu）中注册。
Multiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There is currently no consensus on whether MCS can be established as a distinct disorder. The scoping review of the literature will be guided by five questions: How is MCS defined and which diagnostic criteria have been proposed? What methods are used to report prevalence and incidence estimates of MCS? What are the characteristics of the body of scientific evidence that addresses whether MCS is a distinct disorder or syndrome? What underlying mechanisms for MCS have been proposed in the scientific literature? Which treatment and management approaches for MCS have been evaluated in empirical research studies? We will conduct a comprehensive search in 14 research databases. Citation screening will be supported by machine learning algorithms. Two independent reviewers will assess eligibility of full-text publications against prespecified criteria. Data abstraction will support concise evidence tables. A formal consultation exercise will elicit input regarding the review results and presentation. The existing research evidence will be documented in a user-friendly visualisation in the format of an evidence map. Determined to be exempt from review (UP-22-00516). Results will be disseminated through a journal manuscript and data will be publicly accessible through an online data repository. The protocol is registered in Open Science Framework (osf.io/4a3wu).