Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).
Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).
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DOI：
10.1136/bjophthalmol-2014-305702
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
European Society of Retina Specialists
中科院分区：
文献类型：
--
作者：
Schmidt-Erfurth U;Chong V;Loewenstein A;Larsen M;Souied E;Schlingemann R;Eldem B;Monés J;Richard G;Bandello F;European Society of Retina Specialists
视网膜相关性黄斑变性（AMD）仍然被认为是世界范围内严重和不可逆视力丧失的主要原因。这种疾病对受影响个人的生活质量产生深远影响，由于预期寿命和环境风险呈指数增长，对社会构成重大社会经济挑战。医学研究的进展已经确定血管内皮生长因子（VEGF）是新生血管性AMD中的重要病理生理作用者，并且眼内抑制VEGF是医学中最有效的疗法之一。抗VEGF治疗的广泛引入使得受新生血管性AMD影响的患者的预后得到了压倒性的改善，使得绝大多数患者的视觉功能得以恢复和维持。然而，治疗益处伴随着重大的经济投资、关于使用标签外物质的未解决的法医学争论以及大量人口管理中的压倒性问题。疾病负担已经变成了护理负担，科学进步和现实世界的临床表现脱节。与此同时，诊断技术的突破性创新，如光学相干断层扫描，允许前所未有的高分辨率可视化疾病形态，并为早期疾病检测和有效的治疗随访提供了一个有前途的前景。然而，从形态学参数仍然缺乏明确的结论，有效的生物标志物还有待确定，为疾病管理提供一个实际的基础。欧洲视网膜专家协会为新生血管性AMD的诊断和治疗管理提供专家指导，支持医疗保健人员和医生为患者提供最先进的护理。NCT01318941。
Age-related macular degeneration (AMD) is still referred to as the leading cause of severe and irreversible visual loss world-wide. The disease has a profound effect on quality of life of affected individuals and represents a major socioeconomic challenge for societies due to the exponential increase in life expectancy and environmental risks. Advances in medical research have identified vascular endothelial growth factor (VEGF) as an important pathophysiological player in neovascular AMD and intraocular inhibition of VEGF as one of the most efficient therapies in medicine. The wide introduction of anti-VEGF therapy has led to an overwhelming improvement in the prognosis of patients affected by neovascular AMD, allowing recovery and maintenance of visual function in the vast majority of patients. However, the therapeutic benefit is accompanied by significant economic investments, unresolved medicolegal debates about the use of off-label substances and overwhelming problems in large population management. The burden of disease has turned into a burden of care with a dissociation of scientific advances and real-world clinical performance. Simultaneously, ground-breaking innovations in diagnostic technologies, such as optical coherence tomography, allows unprecedented high-resolution visualisation of disease morphology and provides a promising horizon for early disease detection and efficient therapeutic follow-up. However, definite conclusions from morphologic parameters are still lacking, and valid biomarkers have yet to be identified to provide a practical base for disease management. The European Society of Retina Specialists offers expert guidance for diagnostic and therapeutic management of neovascular AMD supporting healthcare givers and doctors in providing the best state-of-the-art care to their patients. NCT01318941.
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影响因子：
158.5
作者：
Brown, David M.;Kaiser, Peter K.;Schneider, Susan
通讯作者：
Schneider, Susan
影响因子：
--
作者：
Chang, Tom S.;Bressler, Neil M.;Klesert, Todd R.
通讯作者：
Klesert, Todd R.
影响因子：
3.4
作者：
Carneiro, Angela M.;Costa, Raquel;Soares, Raquel
通讯作者：
Soares, Raquel
影响因子：
13.7
作者：
Chakravarthy, U.;Adamis, A. P.;Patel, Manju
通讯作者：
Patel, Manju
影响因子：
4.1
作者：
Avery, Robert L.
通讯作者：
Avery, Robert L.