Founder mutations in the BRCA1 gene in polish families with breast-ovarian cancer
Founder mutations in the BRCA1 gene in polish families with breast-ovarian cancer
复制标题
华蓥山乳腺癌-卵巢癌家族中 BRCA1 基因的创始人突变
DOI：
10.1086/302922
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发表时间：
2000-06-01
影响因子：
9.8
通讯作者：
Lubinski, J
中科院分区：
文献类型：
--
作者：
Górski, B;Byrski, T;Lubinski, J
我们进行了一项以医院为基础的研究，以确定波兰人群中可能存在的 BRCA1 和 BRCA2 创始人突变。该研究小组由 66 个患有癌症的波兰家庭组成，这些家庭中至少有 3 名相关女性患有乳腺癌或卵巢癌，并且这 3 名受影响女性中至少有 1 名在年龄时被诊断出患有癌症。
We have undertaken a hospital-based study, to identify possible BRCA1 and BRCA2 founder mutations in the Polish population. The study group consisted of 66 Polish families with cancer who have at least three related females affected with breast or ovarian cancer and who had cancer diagnosed, in at least one of the three affected females, at age