Break-up of Two-Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer
Break-up of Two-Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer
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DOI：
10.1002/adma.201402572
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发表时间：
2014-11-05
影响因子：
29.4
通讯作者：
Wang, Lianzhou
中科院分区：
文献类型：
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作者：
Chen, Yu;Ye, Delai;Wang, Lianzhou
化学剥离的二维MnO 2纳米片成功地用氨基-聚乙二醇修饰，作为癌症的超灵敏刺激响应治疗诊断学的治疗诊断学平台。高度分散的MnO 2纳米片在肿瘤组织的弱酸性微环境中表现出独特的分解，这可以大大提高它们在T-1加权磁共振成像中的体外和体内性能。这种pH触发的断裂行为可以进一步促进负载的抗癌药物的快速释放，用于同时的pH响应性药物释放，并规避癌细胞的多药耐药性。
Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T-1-weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells.