Gender differences in brain activity evoked by muscle and cutaneous pain: A retrospective study of single-trial fMRI data
Gender differences in brain activity evoked by muscle and cutaneous pain: A retrospective study of single-trial fMRI data
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DOI：
10.1016/j.neuroimage.2007.10.045
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发表时间：
2008-02-15
期刊：
影响因子：
5.7
通讯作者：
Macefield, Vaughan G.
中科院分区：
文献类型：
--
作者：
Henderson, Luke A.;Gandevia, S. C.;Macefield, Vaughan G.
性别对疼痛处理有很大影响。女性不仅表现出更强的疼痛敏感性，而且许多慢性疼痛对女性的影响也大于男性。尽管基于性别的疼痛敏感性差异可能与文化和社会因素有关，但动物研究也揭示了疼痛敏感性的性别差异，这表明生理因素可能导致男性和女性在疼痛处理方面的差异。最近有报道称，有害的皮肤热刺激会引起某些大脑区域基于性别的活动差异。考虑到大多数慢性疼痛，包括那些有性别偏见的慢性疼痛都是“深层”起源（如肌肉、关节或内脏），我们研究了性别差异是否也存在于肌肉疼痛的中枢加工中。在24名健康成人中，我们使用功能性磁共振成像（fMRI）分别测量了肌肉注射和皮下注射高渗盐水引起的肌肉和皮肤疼痛时的信号强度变化。除了激活“疼痛神经基质”，即扣带皮层、岛皮层、体感皮层和小脑皮层外，肌肉疼痛和皮肤疼痛在中扣带皮层、背外侧前额叶皮层、海马和小脑皮层中都会引起基于性别的差异。这些差异可能反映了男性和女性对有害信息的情绪处理的差异，可能是存在于许多慢性疼痛疾病中的性别偏见的基础。Crown Copyright (c) 2007, Elsevier Inc.出版。版权所有。
Gender greatly influences pain processing. Not only do females display greater pain sensitivity, many chronic pain conditions affect females more than males. Although gender-based differences in pain sensitivity may be related to cultural and social factors, animal studies also reveal gender differences in pain sensitivity, suggesting that physiological factors may contribute to differences in the processing of pain in males and females. It has been recently reported that noxious cutaneous heat stimuli evoke gender-based differences in activity in some brain regions. Given that most chronic pain conditions, including those with gender bias are of "deep" origin (e.g. arising in muscle, joints or viscera), we investigated whether gender differences also exist in the central processing of muscle pain. In 24 healthy adults we used functional magnetic resonance imaging (fMRI) to measure signal intensity changes during muscle and cutaneous pain induced by intramuscular and subcutaneous injections of hypertonic saline, respectively. In addition to activating the "pain neuromatrix", i.e. cingulate, insular, somatosensory and cerebellar cortices, both muscle pain and cutaneous pain evoked gender-based differences in the mid-cingulate cortex, dorsolateral prefrontal cortex, hippocampus and cerebellar cortex. These differences may reflect differences in emotional processing of noxious information in men and women and may underlie the gender bias that exists in many chronic pain conditions. Crown Copyright (c) 2007 Published by Elsevier Inc. All rights reserved.