Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
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DOI：
10.1093/jnci/82.11.947
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发表时间：
1990-06
期刊：
影响因子：
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通讯作者：
J. Michnovicz;H. Bradlow
中科院分区：
文献类型：
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作者：
J. Michnovicz;H. Bradlow
十字花科蔬菜中的饮食吲哚诱导细胞色素P450酶，并在各种动物模型中预防肿瘤。由于雌二醇代谢也是细胞色素P450介导的，并与乳腺癌的风险有关，吲哚类药物也可以类似地减少人类雌激素反应性肿瘤。我们研究了几种吲哚在雌性Sprague-Dawley大鼠诱导肝脏雌二醇2-羟基化。最有效的诱导剂，吲哚-3-甲醇，给予人类（500毫克，每天1周）。雌二醇2-羟基化程度（平均值+/- SEM）从29.3% +/- 2.1%显著增加至45.6% +/- 2.1%（P <0.001）。这些结果表明，吲哚-3-甲醇强烈影响雌二醇代谢的人，并可能提供一个新的化学预防方法，雌激素依赖性疾病。
Dietary indoles in cruciferous vegetables induce cytochrome P450 enzymes and have prevented tumors in various animal models. Because estradiol metabolism is also cytochrome P450 mediated and linked to breast cancer risk, indoles may similarly reduce estrogen-responsive tumors in humans. We examined several indoles in female Sprague-Dawley rats for induction of hepatic estradiol 2-hydroxylation. The most potent inducer, indole-3-carbinol, was administered to humans (500 mg daily for 1 wk). It significantly increased the extent (mean +/- SEM) of estradiol 2-hydroxylation from 29.3% +/- 2.1% to 45.6% +/- 2.1% (P less than .001). These results indicate that indole-3-carbinol strongly influences estradiol metabolism in humans and may provide a new chemopreventive approach to estrogen-dependent diseases.