Numerical and Monte Carlo Simulation on X-ray Fluorescence Computed Tomography with Self-Absorption Correction
Numerical and Monte Carlo Simulation on X-ray Fluorescence Computed Tomography with Self-Absorption Correction
复制标题
自吸收校正 X 射线荧光计算机断层扫描的数值和蒙特卡罗模拟
DOI：
10.1166/jmihi.2016.1878
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发表时间：
2016-11
影响因子：
--
通讯作者：
Chen Mianyi
中科院分区：
文献类型：
--
作者：
Jiang Shanghai;Wei Biao;Feng Peng;He Peng;Deng Luzhen;Chen Mianyi
X射线荧光计算机断层扫描（XFCT）作为一种很有前途的成像技术，可以无损、无创地提供样品中微量元素的分布情况。然而，自吸收严重影响了重建图像的质量。通过数值模拟和蒙特卡罗模拟，验证了基于Siddon算法的投影矩阵用于双光束XFCT自吸收校正的可行性。使用数值模拟和蒙特卡罗模拟对包含一个GNP（金纳米颗粒）加载区域（直径= 0.6 cm）的PMMA（聚甲基丙烯酸甲酯）体模（直径= 3.2 cm）进行成像。采用滤波反投影（FBP）、代数重建技术（ART）和最大似然期望最大化（MLEM）3种算法重建图像，计算Au质量浓度、相对误差和对比噪声比（CNR）。
As a promising imaging technique, X-ray fluorescence computed tomography (XFCT) can provide us the distribution of trace elements within samples in a nondestructive and noninvasive manner. However, self-absorption has seriously affected the quality of reconstruction image. In this investigation, the feasibility of projection matrix based on Siddon algorithm used for self-absorption correction in pencil-beam XFCT was test by numerical and Monte Carlo simulation. The PMMA (polymethyl methacrylate) phantom (diameter = 3.2 cm) contained one GNP (gold nanoparticles)-loaded region (diameter = 0.6 cm) is imaged using numerical and Monte Carlo simulation. Three algorithms, including Filter Back Projection (FBP), Algebra Reconstruction Technique (ART) and maximum likelihood expectation maximization (MLEM), were used to reconstruct images, then, Au weight concentration, relative error and contrast-to-noise (CNR) were calculated.