Water manganese exposure and children's intellectual function in Araihazar, Bangladesh.
Water manganese exposure and children's intellectual function in Araihazar, Bangladesh.
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DOI：
10.1289/ehp.8030
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发表时间：
2006-01
影响因子：
10.4
通讯作者：
Graziano JH
中科院分区：
文献类型：
--
作者：
Wasserman GA;Liu X;Parvez F;Ahsan H;Levy D;Factor-Litvak P;Kline J;van Geen A;Slavkovich V;LoIacono NJ;Cheng Z;Zheng Y;Graziano JH
长期以来，通过吸入暴露于锰会引起成人神经毒性，但对通过饮用水暴露的可能后果知之甚少。在这项研究中，我们报告了对孟加拉国Araihazar的142名10岁儿童的智力功能进行横断面调查的结果，这些儿童一直饮用平均浓度为793 μg Mn/L和3 μg砷/L的管井水。孩子们和母亲们来到我们的野外诊所，在那里孩子们接受了体检，测量了体重、身高和头围。儿童的智力功能进行了评估的测试，从韦氏儿童智力量表，第三版，通过汇总加权项目跨域创建口头，性能和全量表原始分数。儿童提供尿液样本测量尿砷和肌酐，并要求提供血液样本测量血铅，砷，锰和血红蛋白浓度。调整后的社会人口统计学协变量，水锰与减少全量表，性能和口头原始分数，在剂量反应的方式，低水平的水中没有影响。在美国，大约6%的家庭威尔斯井中的锰浓度超过300 μg Mn/L，这是美国环境保护署目前的终身健康咨询水平。我们的结论是，在孟加拉国和美国，一些儿童有锰诱导的神经毒性的风险。
Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Araihazar, Bangladesh, who had been consuming tube-well water with an average concentration of 793 μg Mn/L and 3 μg arsenic/L. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children’s intellectual function was assessed on tests drawn from the Wechsler Intelligence Scale for Children, version III, by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead, As, Mn, and hemoglobin concentrations. After adjustment for sociodemographic covariates, water Mn was associated with reduced Full-Scale, Performance, and Verbal raw scores, in a dose–response fashion; the low level of As in water had no effect. In the United States, roughly 6% of domestic household wells have Mn concentrations that exceed 300 μg Mn/L, the current U.S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity.