Different activation dynamics in multiple neural systems during simulated driving
Different activation dynamics in multiple neural systems during simulated driving
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DOI：
10.1002/hbm.10032
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发表时间：
2002-07-01
影响因子：
4.8
通讯作者：
Pearlson, GD
中科院分区：
文献类型：
--
作者：
Calhoun, VD;Pekar, JJ;Pearlson, GD
驾驶是一种复杂的行为，涉及多种认知元素。我们报告了一项模拟驾驶的成像研究，揭示了多个神经系统，每个系统都有不同的激活动力学。用功能磁共振成像技术识别驾驶行为的神经相关性，并研究其对速度的调制。我们使用一种新的，普遍适用的方法，独立组件分析的基础上分解成可解释的激活件。某些区域打开或关闭，其他区域呈现逐渐衰减，而其他区域在开始或停止驾驶时瞬时打开。前扣带皮层的信号通常与错误监控和抑制有关，它以与驾驶速度成比例的速率呈指数下降，而额顶叶区域的信号则与速度有关，与警惕有关。小脑和枕叶区域的增加，可能与复杂的视觉整合有关，在驾驶过程中被激活，但与驾驶速度无关。(C)2002 Wiley-Liss，Inc.
Driving is a complex behavior that recruits multiple cognitive elements. We report on an imaging study of simulated driving that reveals multiple neural systems, each of which have different activation dynamics. The neural correlates of driving behavior are identified with fMRI and their modulation with speed is investigated. We decompose the activation into interpretable pieces using a novel, generally applicable approach, based upon independent component analysis. Some regions turn on or Off, others exhibit a gradual decay, and yet others turn on transiently when starting or stopping driving. Signal in the anterior cingulate cortex, an area often associated with error monitoring and inhibition, decreases exponentially with a rate proportional to driving speed, whereas decreases in frontoparietal regions, implicated in vigilance, correlate with speed. Increases in cerebellar and occipital areas, presumably related to complex visuomotor integration, are activated during driving but not associated with driving speed. (C) 2002 Wiley-Liss, Inc.