BLIMP1 guides the fate of effector B and T cells
BLIMP1 guides the fate of effector B and T cells
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DOI：
10.1038/nri2204
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发表时间：
2007-12-01
影响因子：
100.3
通讯作者：
Kallies, Axel
中科院分区：
文献类型：
--
作者：
Nutt, Stephen L.;Fairfax, Kirsten A.;Kallies, Axel
B淋巴细胞诱导成熟蛋白1（BLIMP1）是一种转录抑制因子，其在控制抗体分泌细胞（ASCs）终末分化中的重要性已得到充分证实。然而，正如我们在这篇进展文章中讨论的那样，现在已经很明显，ASC程序包括一个独立的BLIMP1启动阶段，然后是第二步，其中BLIMP1是完全成熟ASC分化所必需的。此外，BLIMP1在维持效应T细胞稳态中的重要作用正在显现，这表明B细胞和T细胞中效应细胞命运的控制之间存在有趣的相似之处。
B-lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor, and its importance in controlling the terminal differentiation of antibody-secreting cells (ASCs) is well established. However, as we discuss in this Progress article, it has now become evident that the ASC programme consists of a discrete BLIMP1-independent initiation phase, followed by a second step in which BLIMP1 is absolutely required for the differentiation of fully mature ASCs. In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells.