Basic study for diagnosing blood vessel plaque employing ultrasonic velocity-change imaging in combination with near-infrared illumination
Basic study for diagnosing blood vessel plaque employing ultrasonic velocity-change imaging in combination with near-infrared illumination
复制标题
超声变速成像结合近红外照明诊断血管斑块的基础研究
DOI：
10.1007/s10043-015-0097-2
复制
发表时间：
2015
期刊：
影响因子：
1.2
通讯作者：
H. Horinaka
中科院分区：
文献类型：
--
作者：
K. Mano;Shohei Tanigawa;K. Wada;T. Matsunaka;H. Horinaka
在早期发现不稳定的血管斑块，以防止其脱离和随后的心肌或脑梗死是很重要的。斑块的不稳定性取决于内部脂质核心的大小和分布。我们提出了一种通过近红外激光加热后超声传播速度变化来识别脂质结构域的方法。首先，我们证明了最有效的脂肪组织加热诱导超声速度变化是用935纳米激光。接下来，构建一个包含内部脂质结构域的柔性血管模体，并将其连接到脉动泵上。实验表明，即使在存在流动脉动的情况下，超声速度变化成像也能识别出脂质结构域。我们认为光学照明下的超声速度变化成像可能是诊断血管斑块存在的有效技术。
It is important to detect unstable blood vessel plaques at an early stage to prevent their detachment and subsequent myocardial or brain infarctions. The instability of such plaques depends on the size and distribution of the internal lipid core. We propose a method for identifying lipid domains by changes in the ultrasound propagation velocity after warming with a near-infrared laser. First, we demonstrate that the most effective warming of fatty tissue to induce ultrasonic velocity changes is with a 935-nm laser. Next, a compliant blood vessel phantom containing an internal lipid domain was constructed and attached to a pulsatile pump. Experiments showed that the lipid domain could be identified with ultrasonic velocity-change imaging even in the presence of flow pulsation. We submit that ultrasonic velocity-change imaging under optical illumination may be an effective technique for diagnosing the presence of blood vessel plaques.