A Monte Carlo simulation for Moving Light Source in Intracavity PDT.
A Monte Carlo simulation for Moving Light Source in Intracavity PDT.
复制标题
腔内 PDT 中移动光源的蒙特卡罗模拟。
DOI：
10.1117/12.2649538
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sourvanos,Dennis
中科院分区：
文献类型：
--
作者：
Parilov,Evgueni;Beeson,Karl;Potasek,Mary;Zhu,Timothy;Sun,Hongjing;Sourvanos,Dennis
我们开发了一种模拟方法，用于模拟使用移动光源的胸腔内光动力学治疗（icav-PDT）中的光通量输送。由于胸膜肺腔的表面积很大，需要移动光源以在整个腔体周围输送均匀的剂量。虽然多个固定的探测器用于在几个位置的剂量测定，一个精确的模拟光通量和通量率仍然需要为其余的腔。我们扩展了现有的基于蒙特卡罗（MC）的光传播求解器，通过对连续光源轨迹进行密集采样并分配适当数量的光子包（沿沿着发射）来支持移动光源。Simphotek GPU基于CUDA的方法实现- PEDSy-MC -的性能已经在真人大小的肺形体模上得到了证明，该体模是为测试Perlman医学院（PSM）的icav-PDT导航系统而定制打印的-计算在一分钟内完成（对于某些情况），并在几分钟内完成。我们证明了在5%的误差范围内的多个探测器在幻影的解析解的结果。PEDSy-MC配备了一个剂量腔可视化工具，可以在2D和3D中实时检查治疗腔的剂量值，该工具将扩展到PSM正在进行的临床试验中。PSM开发了一种技术，使用Photofrin介导的PDT测量胸腔体模中的8个探测器，该技术已在确认期间使用。
We developed a simulation method for modeling the light fluence delivery in intracavity Photodynamic Therapy (icav-PDT) for pleural lung cancer using a moving light source. Due to the large surface area of the pleural lung cavity, the light source needs to be moved to deliver a uniform dose around the entire cavity. While multiple fixed detectors are used for dosimetry at a few locations, an accurate simulation of light fluence and fluence rate is still needed for the rest of the cavity. We extended an existing Monte Carlo (MC) based light propagation solver to support moving light sources by densely sampling the continuous light source trajectory and assigning the proper number of photon packages launched along the way. The performance of Simphotek GPU CUDA-based implementation of the method – PEDSy-MC – has been demonstrated on a life-size lung-shaped phantom, custom printed for testing icav-PDT navigation system at the Perlman School of Medicine (PSM) – calculations completed under a minute (for some cases) and within minutes have been achieved. We demonstrate results within a 5% error of the analytic solution for multiple detectors in the phantom. PEDSy-MC is accompanied by a dose-cavity visualization tool that allows real-time inspection of dose values of the treated cavity in 2D and 3D, which will be expanded to ongoing clinical trials at PSM. PSM has developed a technology to measure 8-detectors in a pleural cavity phantom using Photofrin-mediated PDT that has been used during validation.