Transformation of 3DP gypsum model to HA by treating in ammonium phosphate solution
Transformation of 3DP gypsum model to HA by treating in ammonium phosphate solution
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DOI：
10.1002/jbm.b.30609
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发表时间：
2007-02-01
影响因子：
3.4
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Lowmunkong, Rungnapa;Sohmura, Taiji;Ishikawa, Kunio
三维打印（3DP）是一种使用喷墨打印技术建立的CAD/CAM。商业上可获得的3DP系统只能形成石膏模型而不能用于生物陶瓷。另一方面，最近发现通过在磷酸铵溶液中处理将硬化石膏转化为羟基磷灰石（HA）。在本研究中，尝试将3DP石膏块转化为HA。然而，制造的3DP块可溶于水。为了不溶解，将其在300摄氏度下加热10分钟，然后将石膏转化为半水合硫酸钙CaSO 4（.）0.5H（2）O.将3D块浸入1 M（NH 4）（3）PO 4（.）3 H（2）O溶液在80 ℃下处理1-24 h，确定在4 h内转化为HA。热处理石膏的巴黎（POP）块也进行了研究比较。未加热的二水石膏组成的POP块需要24 h才能完成转化，而热处理的半水硫酸钙组成的POP促进转化为HA;但块中的转化厚度小于3DP块。这可能是由于半水合物的溶解度高于石膏二水合物。3DP块的加速转化也是由其多孔结构引起的，这使得磷酸盐溶液易于渗透。利用本发明的方法，可以通过3D打印将所制造的石膏转化为HA假体或支架，所述3D打印适应于骨缺损。(c)2006 Wiley Periodicals，Inc.
Three-dimensional printing (3DP) is a CAD/CAM built-up using ink-jet printing technique. Commercially available 3DP system can form only gypsum model and not for bioceramics. On the other hand, transformation of hardened gypsum into hydroxyapatite (HA) by treatment in ammonium phosphate solution was found lately. In the present study, transformation of the 3DP gypsum block to HA was attempted. However, the fabricated 3DP block was soluble in water. To insolubilize, it was heated at 300 degrees C for 10 min, and then, gypsum was transformed to calcium sulfate hemihydrate, CaSO4 (.) 0.5H(2)O. The 3D block was immersed in 1M (NH4)(3)PO4 (.) 3H(2)O solution at 80 degrees C for 1-24 h, and the transformation into HA within 4 h was ascertained. A heat-treated plaster of Paris (POP) block was also investigated for comparison. The unheated POP block consisting of gypsum dihydrate took 24 h to complete the transformation, while the heat-treated POP consisting calcium sulfate hemihydrate promoted the transformation into HA; but the transformed thickness in the block was less than the 3DP block. This is probably due to higher solubility of the hemihydrate than gypsum dihy drate. Accelerated transformation of the 3DP block was also caused by its porous structure, which enabled an easy penetration of the phosphate solution. With the present method, it is possible to transform the fabricated gypsum by 3D printing that is adaptive to the osseous defect into HA prostheses or scaffold. (c) 2006 Wiley Periodicals, Inc.